EG665186 Activators
Zona Pellucida Like Domain Containing 2 (ZPLD2) Activators encompasses a diverse array of chemical compounds that enhance the functional activity of ZPLD2 through various signaling pathways. Phorbol 12-myristate 13-acetate (PMA) functions by activating protein kinase C (PKC), a key regulator of numerous signaling cascades, which could lead to the phosphorylation of proteins involved in the zona pellucida, including ZPLD2, thereby enhancing its activity. The action of PMA on PKC is complemented by the mechanism of Ionomycin, which raises intracellular calcium levels and can thereby enhance ZPLD2 function via calcium-dependent protein kinases, known to play a crucial role in the structural integrity of the zona pellucida. Forskolin works by increasing cyclic AMP (cAMP) levels, which could in turn activate protein kinase A (PKA) and promote the phosphorylation of proteins that enhance the function of ZPLD2.
The compound A23187, as a calcium ionophore, mimics the cellular influx of calcium and potentially enhances ZPLD2 activity by activating calcium-dependent signaling pathways. In conjunction with A23187, Genistein's inhibition of tyrosine kinases could prevent dephosphorylation of proteins involved in zona pellucida function, thereby maintaining or enhancing ZPLD2 activity. LY294002 and Wortmannin, both inhibitors of phosphoinositide 3-kinases (PI3K), could indirectly enhance ZPLD2 by modulating the downstream AKT signaling pathway, which is implicated in the regulation of zona pellucida formation and function. U73122 and KN-93, by inhibiting phospholipase C and CaMKII respectively, could enhance ZPLD2 activity through the modulation of calcium signaling and downstream kinases that are pivotal to the structural maintenance of the zona pellucida.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A potent activator of protein kinase C (PKC) which can enhance Zona Pellucida Like Domain Containing 2 (ZPLD2) by promoting phosphorylation events that could lead to its functional activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Calcium ionophore that increases intracellular calcium concentration, potentially enhancing ZPLD2 by calcium-dependent protein kinase pathways which are known to be involved in zona pellucida formation and function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that can mimic cellular calcium influx, potentially enhancing ZPLD2 activity by stimulating calcium-dependent signaling mechanisms associated with egg-sperm fusion. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A tyrosine kinase inhibitor that can enhance ZPLD2 by inhibiting competing phosphorylation pathways, allowing for specific kinase pathways to preferentially activate ZPLD2 related processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that can increase ZPLD2 activity through the modulation of downstream AKT signaling, which can have an impact on zona pellucida dynamics and sperm binding. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
A calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitor that can enhance ZPLD2 by affecting downstream signaling pathways that influence zona pellucida structure and integrity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that can enhance ZPLD2 function by modulating stress-activated protein kinase pathways, which may influence zona pellucida composition and sperm-egg interaction. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An MEK inhibitor that can enhance ZPLD2 through the inhibition of ERK signaling, potentially affecting the regulation of zona pellucida proteins and their function in fertilization. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
A broad PKC inhibitor that could enhance ZPLD2 by selectively modulating PKC isoforms, potentially affecting pathways that regulate zona pellucida formation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor that can enhance ZPLD2 activity by altering the PI3K/AKT pathway, which is potentially involved in the regulation of zona pellucida characteristics and function during fertilization. | ||||||