EG636741 Activators
Zfp964Activators is a diverse chemical class defined by their ability to modulate the activity of zinc finger protein 964 (Zfp964), a member of the zinc finger protein family of transcription factors. These activators are not unified by a common chemical structure but by their functional outcome, which is the enhancement of Zfp964's interaction with DNA and its transcriptional regulation. The members of this class include a variety of organic molecules, such as forskolin, a labdane diterpene that directly stimulates adenylyl cyclase to increase intracellular cAMP levels, and phorbol esters like phorbol 12-myristate 13-acetate (PMA), which mimic diacylglycerol (DAG) and activate protein kinase C (PKC). Other members, like ionomycin, increase intracellular calcium levels and can engage calcium-dependent signaling pathways, while epidermal growth factor (EGF) operates through receptor tyrosine kinase pathways, initiating cascades that can culminate in transcription factor activation. This broad range of molecules can influence the transcriptional process either by direct interaction with the transcription factors or by altering the accessibility of transcription factors to the DNA through modifications of the chromatin structure.
The molecules within the Zfp964Activators class also include compounds that affect transcription by modulating epigenetic marks or cellular signaling pathways. Histone deacetylase inhibitors such as trichostatin A (TSA) and sodium butyrate relax the chromatin structure, which increases the accessibility of Zfp964 to its DNA binding sites. In contrast, 5-Azacytidine inhibits DNA methyltransferases, which can lead to changes in DNA methylation patterns and, consequently, gene expression profiles. Furthermore, molecules like resveratrol, which activates sirtuin 1 (SIRT1), affect deacetylation processes within the cell, modifying the activity of both histones and non-histone proteins. The diversity of Zfp964Activators reflects the complex nature of transcription regulation, where multiple biochemical routes converge to control the expression of genes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that activates protein kinase C (PKC). PKC plays a role in several signaling pathways and can phosphorylate transcription factors. Phosphorylation by PKC can enhance the DNA binding activity of zinc finger proteins, thereby indirectly enhancing the functional activity of zinc finger protein 964. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Calcium acts as a second messenger in various signaling pathways, including those involving calmodulin-dependent kinase (CaMK), which can phosphorylate and enhance the activity of transcription factors. This can lead to enhanced activity of zinc finger protein 964 through increased DNA binding and transcriptional regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid binds to retinoic acid receptors which heterodimerize with retinoid X receptors. These complexes can interact with zinc finger proteins on DNA binding sites, enhancing the transcriptional activity of genes controlled by zinc finger protein 964. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3). Inhibition of GSK-3 stabilizes transcription factors and enhances their activity. This stabilization can indirectly enhance the activity of zinc finger protein 964 by promoting its interaction with other transcription factors and coactivators. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is a histone deacetylase inhibitor that leads to a more relaxed chromatin structure, allowing easier access for transcription factors. This can enhance the activity of zinc finger protein 964 by facilitating its binding to DNA and its transcriptional regulation capabilities. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB signaling, which results in the alteration of the transcriptional activity of various genes. By affecting NF-κB pathway, curcumin can enhance the activity of zinc finger protein 964 by reducing competitive inhibition or by changing the transcriptional environment to favor zinc finger protein 964-mediated transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is another histone deacetylase inhibitor, which, like TSA, leads to a more open chromatin structure. This enhances the activity of transcription factors including zinc finger protein 964 by improving their access to DNA. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), which deacetylates proteins and can lead to changes in chromatin structure and gene expression. By activating SIRT1, resveratrol can indirectly enhance the activity of zinc finger protein 964 by affecting the transcriptional regulation of genes it controls. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, which can lead to hypomethylation of DNA and subsequent changes in gene expression. Hypomethylation may enhance the activity of zinc finger protein 964 by increasing its access to DNA binding sites and enhancing transcription. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, similarly to forskolin. The resulting activation of PKA can lead to the phosphorylation of transcription factors and enhance their activity, including that of zinc finger protein 964, by promoting DNA binding and transcriptional activity. | ||||||