EG635895 Activators
The chemical class EG635895 Activators comprises compounds that influence the activity of serine/threonine kinases through various mechanisms. These activators utilize diverse cellular signaling pathways and regulatory mechanisms to exert their effects. Forskolin, for instance, elevates cAMP levels, leading to the activation of PKA, which in turn may phosphorylate and activate downstream kinases, including serine/threonine kinases like EG635895. PMA and ionomycin both modulate PKC and calcium-dependent kinases, respectively, and these activated kinases can phosphorylate multiple substrates, leading to the activation of kinases in the same class as EG635895.
Lithium chloride and EGCG work through GSK-3 inhibition and modulation of signaling pathways related to oxidative stress, leading to changes in kinase activity. The increase in phosphorylation due to the inhibition of phosphatases by okadaic acid or the direct activation of PKA by db-cAMP can also result in the activation of EG635895 or its homologs.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) by mimicking the action of diacylglycerol (DAG), a second messenger. PKC, in turn, can activate a multitude of downstream serine/threonine kinases, possibly including EG635895. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 increases intracellular calcium levels, which can activate calmodulin and calcium/calmodulin-dependent protein kinases (CaMKs), potentially leading to the activation of downstream kinases like EG635895. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within the cell which could indirectly increase the activity of EG635895 through reduced dephosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases (SAPKs) and JNK, which may enhance the activation of related serine/threonine kinases such as EG635895. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially activating calcium-dependent protein kinases that might then lead to activation of EG635895. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3), which may have downstream effects on signaling pathways that result in the activation of serine/threonine kinases like EG635895. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, leading to the activation of PKA and subsequent activation of downstream kinases, potentially including EG635895. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can modulate various signaling pathways, including those involving kinases, by its antioxidant properties, potentially affecting the redox state of cells and the activity of redox-sensitive kinases like EG635895. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
db-cAMP is a cell-permeable analogue of cAMP that directly activates PKA, potentially enhancing the phosphorylation and activation of downstream kinases, possibly including EG635895. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Although known as a broad-spectrum kinase inhibitor, staurosporine at low concentrations can paradoxically activate certain kinases before inhibitory effects prevail, which might affect EG635895 activity. | ||||||