EG625716 Inhibitors
Slco1a8, a member of the solute carrier organic anion transporter family, plays a crucial role in bile acid and organic anion transport. The protein is predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity, functioning as an integral component of the plasma membrane. Slco1a8's involvement in bile acid transport is vital for maintaining homeostasis and metabolic processes. The predicted functions of enabling bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity highlight its significance in mediating the movement of bile acids and organic anions across cell membranes.
The inhibition of Slco1a8 involves various mechanisms that target its predicted functions and related transport processes. Inhibitors such as rifampicin and ketoconazole modulate CYP3A4, impacting bile acid metabolism and indirectly influencing Slco1a8-mediated bile acid transmembrane transport. Compounds like glyburide and bosentan inhibit specific transporters, affecting sodium-independent organic anion transport and indirectly influencing Slco1a8 function. The competition for binding sites, as seen with digoxin as a substrate, and the inhibition of related transporters, like OATP1B1 and OATP2B1, by various chemicals, collectively contribute to the modulation of Slco1a8-mediated transport processes. These mechanisms of inhibition provide insights into the complex regulatory networks governing bile acid and organic anion transport and contribute to our understanding of Slco1a8's role in cellular physiology.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Inducer of CYP3A4 affecting bile acid metabolism. Rifampicin induces CYP3A4, leading to increased bile acid biotransformation, indirectly influencing Slco1a8-mediated bile acid transmembrane transport. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Inhibitor of CYP3A4 affecting bile acid metabolism. Ketoconazole inhibits CYP3A4, causing a reduction in bile acid biotransformation, indirectly impacting Slco1a8-mediated bile acid transmembrane transport. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $46.00 $61.00 $117.00 $173.00 $530.00 | 36 | |
Inhibitor of OATP1A2 affecting sodium-independent organic anion transport. Glyburide inhibits OATP1A2, indirectly influencing Slco1a8-mediated sodium-independent organic anion transport by modulating the function of related transporters. | ||||||
Ritonavir | 155213-67-5 | sc-208310 | 10 mg | $124.00 | 7 | |
Inhibitor of OATP1B1 affecting bile acid transport. Ritonavir inhibits OATP1B1, impacting bile acid transport and indirectly influencing Slco1a8-mediated bile acid transmembrane transport. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Inhibitor of MRP2 affecting bile acid transport. Mycophenolic acid inhibits MRP2, impacting bile acid transport and indirectly influencing Slco1a8-mediated bile acid transmembrane transport by modulating the function of related transporters. | ||||||
Bosentan | 147536-97-8 | sc-210957 | 10 mg | $195.00 | 3 | |
Inhibitor of OATP1B3 affecting sodium-independent organic anion transport. Bosentan inhibits OATP1B3, indirectly influencing Slco1a8-mediated sodium-independent organic anion transport by modulating the function of related transporters. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Inhibitor of OATP2B1 affecting bile acid transport. Cimetidine inhibits OATP2B1, impacting bile acid transport and indirectly influencing Slco1a8-mediated bile acid transmembrane transport. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Inhibitor of MRP4 affecting sodium-independent organic anion transport. Probenecid inhibits MRP4, indirectly influencing Slco1a8-mediated sodium-independent organic anion transport by modulating the function of related transporters. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
Inhibitor of OATP1B1 affecting bile acid transport. Atorvastatin inhibits OATP1B1, impacting bile acid transport and indirectly influencing Slco1a8-mediated bile acid transmembrane transport by modulating the function of related transporters. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $143.00 $694.00 | ||
Substrate of OATP2B1 affecting sodium-independent organic anion transport. 12β-Hydroxydigitoxin competes with other substrates for OATP2B1 binding, indirectly influencing Slco1a8-mediated sodium-independent organic anion transport by modulating the competition for transporter binding sites. | ||||||