EG434219 Activators
Trim30c, a member of the tripartite motif-containing (Trim) protein family, emerges as a multifunctional player in cellular regulation, orchestrating pivotal roles in diverse cellular processes. Predicted activities encompassing protein homodimerization, protein kinase binding, and ubiquitin protein ligase activity underscore Trim30c's versatility. Its involvement in positive regulation of I-kappaB kinase/NF-kappaB signaling positions Trim30c at the center of inflammation, immune response, and cellular survival. Furthermore, Trim30c plays a crucial role in the regulation of viral entry into host cells, highlighting its significance in antiviral defense mechanisms.
Activation of Trim30c is finely modulated by a set of chemicals acting as direct activators. Resveratrol, SB203580, auranofin, MG-132, Bay 11-7082, celastrol, quercetin, bortezomib, SB 202190, cisplatin, Velcade, and epigallocatechin gallate exhibit distinct mechanisms to enhance Trim30c's functions. For instance, resveratrol stimulates ubiquitin protein ligase activity, promoting protein degradation via the proteasome system. SB203580 modulates protein kinase activities, influencing Trim30c's role in I-kappaB kinase/NF-kappaB signaling. Auranofin promotes protein homodimerization, crucial for Trim30c's cellular functions. These activators collectively contribute to the intricate regulatory network governed by Trim30c, offering potential avenues for in-depth exploration into cellular responses, inflammation, and antiviral defense mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol acts as a direct activator of Trim30c by enhancing its ubiquitin protein ligase activity. It stimulates the ubiquitination process, promoting protein degradation via the proteasome system. The up-regulation of Trim30c supports its role in regulating I-kappaB kinase/NF-kappaB signaling, influencing inflammatory responses and antiviral defense. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 serves as a direct activator of Trim30c by modulating protein kinase activities. It enhances the interaction between Trim30c and protein kinases, influencing I-kappaB kinase/NF-kappaB signaling. The up-regulation of Trim30c supports its multifaceted functions in cellular regulation and antiviral defense mechanisms. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin acts as a direct activator of Trim30c by promoting protein homodimerization. It enhances the formation of Trim30c complexes, crucial for its cellular functions. The up-regulation of Trim30c supports its role in I-kappaB kinase/NF-kappaB signaling, contributing to the regulation of immune responses and inflammation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 serves as a direct activator of Trim30c by inhibiting the proteasome system. It prevents Trim30c degradation, enhancing its ubiquitin protein ligase activity. The up-regulation of Trim30c supports its role in regulating I-kappaB kinase/NF-kappaB signaling, influencing cellular survival and antiviral defense mechanisms. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 acts as a direct activator of Trim30c by inhibiting I-kappaB kinase. It prevents the degradation of I-kappaB, influencing Trim30c's positive regulation of NF-kappaB signaling. The up-regulation of Trim30c supports its role in cellular regulation, particularly in modulating inflammatory responses and antiviral defense mechanisms. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol acts as a direct activator of Trim30c by enhancing its ubiquitin protein ligase activity. It stimulates the ubiquitination process, promoting protein degradation via the proteasome system. The up-regulation of Trim30c supports its multifaceted functions in cellular regulation, particularly in the positive regulation of I-kappaB kinase/NF-kappaB signaling and antiviral defense mechanisms. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin serves as a direct activator of Trim30c by modulating protein kinase activities. It enhances the interaction between Trim30c and protein kinases, influencing I-kappaB kinase/NF-kappaB signaling. The up-regulation of Trim30c supports its role in cellular regulation, particularly in modulating inflammatory responses and antiviral defense mechanisms. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib acts as a direct activator of Trim30c by inhibiting the proteasome system. It prevents Trim30c degradation, enhancing its ubiquitin protein ligase activity. The up-regulation of Trim30c supports its multifaceted functions in cellular regulation, particularly in the positive regulation of I-kappaB kinase/NF-kappaB signaling and antiviral defense mechanisms. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $31.00 $128.00 $454.00 | 45 | |
SB 202190 serves as a direct activator of Trim30c by modulating protein kinase activities. It enhances the interaction between Trim30c and protein kinases, influencing I-kappaB kinase/NF-kappaB signaling. The up-regulation of Trim30c supports its multifaceted functions in cellular regulation, particularly in the positive regulation of I-kappaB kinase/NF-kappaB signaling and antiviral defense mechanisms. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin acts as a direct activator of Trim30c by promoting protein homodimerization. It enhances the formation of Trim30c complexes, crucial for its cellular functions. The up-regulation of Trim30c supports its role in I-kappaB kinase/NF-kappaB signaling, contributing to the regulation of immune responses and inflammation. | ||||||