EG434219 inhibitors are a class of chemical compounds specifically designed to target and inhibit the activity of the molecule EG434219, which is likely involved in key regulatory processes within cellular signaling or enzymatic pathways. EG434219 is presumed to play a critical role in modulating biochemical interactions or protein functions that are essential for maintaining cellular homeostasis. This molecule may be engaged in processes such as protein phosphorylation, dephosphorylation, or signal transduction, serving as a regulatory checkpoint in various cellular networks. Inhibition of EG434219 interferes with its ability to interact with target substrates or signaling molecules, thereby altering the biological pathways it regulates. These inhibitors provide a valuable tool for exploring the precise role of EG434219 in cellular processes and its impact on the broader biochemical landscape.
Structurally, EG434219 inhibitors are designed to bind to specific functional sites on the EG434219 molecule, such as its active site or allosteric sites that are crucial for its activity. These inhibitors may function through competitive inhibition, where they directly block the interaction between EG434219 and its substrates, or through non-competitive mechanisms that induce conformational changes, reducing the molecule's functional capabilities. By inhibiting EG434219, researchers can study the downstream effects on cellular pathways that rely on its activity, providing insights into how this molecule controls processes like protein-protein interactions, signal transduction, or metabolic regulation. This research helps to illuminate the role of EG434219 in maintaining cellular organization, contributing to the broader understanding of how regulatory molecules modulate complex biological systems and ensure proper cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Inhibits NF-kappaB signaling by preventing I-kappaB kinase activation, thereby downregulating Trim30c-mediated positive regulation of I-kappaB kinase/NF-kappaB signaling. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor blocking ubiquitin-proteasome-dependent degradation, disrupting Trim30c's ubiquitin protein ligase activity and stabilizing proteins involved in NF-kappaB signaling pathways. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
Selectively inhibits nuclear translocation of NF-kappaB, counteracting Trim30c-mediated positive regulation of NF-kappaB transcription factor activity. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Modulates multiple cellular pathways, including NF-kappaB signaling, indirectly inhibiting Trim30c's role in positive regulation of I-kappaB kinase/NF-kappaB signaling. | ||||||
ML 120B Dihydrochloride | 783348-36-7 (free base) | sc-487759 | 5 mg | $380.00 | ||
Inhibits TAK1, a kinase in the NF-kappaB pathway, leading to reduced NF-kappaB signaling and countering Trim30c's positive regulation of I-kappaB kinase/NF-kappaB signaling. | ||||||
Wedelolactone | 524-12-9 | sc-200648 sc-200648A | 1 mg 5 mg | $110.00 $337.00 | 8 | |
Blocks IkappaB kinase activity, inhibiting NF-kappaB signaling and mitigating Trim30c's positive regulation of I-kappaB kinase/NF-kappaB signaling. | ||||||
Embelin | 550-24-3 | sc-201555 sc-201555A | 10 mg 50 mg | $89.00 $339.00 | 5 | |
Selectively inhibits XIAP, disrupting the inhibition of caspases and inducing apoptosis, potentially affecting Trim30c-mediated regulation of NF-kappaB signaling. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Inhibits IkappaB kinase and NF-kappaB activation, reducing Trim30c's positive regulation of I-kappaB kinase/NF-kappaB signaling. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Proteasome inhibitor preventing degradation of IkappaB, leading to reduced NF-kappaB signaling and counteracting Trim30c-mediated positive regulation of I-kappaB kinase/NF-kappaB signaling. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $133.00 | 12 | |
Inhibits IKK-2, a key component of NF-kappaB signaling, attenuating Trim30c's positive regulation of I-kappaB kinase/NF-kappaB signaling. | ||||||