EG236451 Activators
Phf11b, a member of the PHD finger protein family, plays a pivotal role in cellular processes with its predicted localization in the nuclear membrane and nucleoplasm. Positioned in the nucleus, Phf11b is implicated in the regulation of various cellular functions, acting as a modulator of gene expression. The general mechanisms of Phf11b activation involve intricate molecular interactions and signaling cascades influenced by specific chemicals.
The direct and indirect activators identified for Phf11b shed light on its sensitivity to epigenetic modifications and cellular responses. Chemicals like retinoic acid directly activate Phf11b by binding to retinoic acid receptors, modulating gene transcription. HDAC inhibitors, such as SAHA and TSA, indirectly upregulate Phf11b by fostering histone acetylation and altering chromatin dynamics. Etoposide triggers a DNA damage response, indirectly influencing Phf11b expression. Valproic acid and curcumin impact chromatin structure through HDAC inhibition, linking epigenetic modifications to Phf11b modulation. JQ1 disrupts chromatin interactions, releasing BET proteins and indirectly activating Phf11b. The diverse mechanisms underline Phf11b's adaptability to various cellular contexts and stimuli. Activation of Phf11b reflects its involvement in chromatin dynamics, epigenetic modifications, and cellular responses to DNA damage. Understanding the nuanced activation of Phf11b provides valuable insights into its role as a regulator of gene expression and its contribution to cellular homeostasis. The interplay between specific chemicals and Phf11b activation mechanisms unravels a complex network that governs its function, offering a foundation for further exploration of Phf11b in diverse cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid activates Phf11b by binding to retinoic acid receptors, influencing gene transcription. This direct activation involves retinoic acid receptor-mediated upregulation of Phf11b expression in the nucleus, underscoring the role of retinoic acid signaling in modulating Phf11b activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA activates Phf11b through HDAC inhibition, fostering histone acetylation. Altered chromatin structure indirectly enhances Phf11b expression in the nucleus, providing a molecular link between HDAC inhibition and Phf11b activation, reflecting the impact of epigenetic regulation on Phf11b. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA activates Phf11b by inhibiting HDAC, promoting histone acetylation. Altered chromatin dynamics indirectly enhance Phf11b expression in the nucleus, highlighting the role of TSA in modulating Phf11b activity through epigenetic modifications. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide activates Phf11b by influencing DNA topoisomerase II activity. The resulting DNA damage triggers a response that indirectly upregulates Phf11b expression in the nucleus, emphasizing the link between DNA damage response and Phf11b activation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid activates Phf11b through HDAC inhibition, promoting histone acetylation. Altered chromatin structure indirectly enhances Phf11b expression in the nucleus, establishing a connection between valproic acid and the modulation of Phf11b activity through epigenetic modifications. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 activates Phf11b by inhibiting BET proteins, disrupting chromatin interactions. The consequent release of BET proteins from chromatin indirectly upregulates Phf11b expression in the nucleus, revealing the impact of chromatin dynamics on Phf11b activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates Phf11b through modulation of histone acetylation. Its impact on chromatin dynamics indirectly enhances Phf11b expression in the nucleus, illustrating the connection between curcumin-mediated epigenetic modifications and the modulation of Phf11b activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine activates Phf11b by DNA demethylation, influencing gene transcription. The demethylating effect indirectly upregulates Phf11b expression in the nucleus, highlighting the sensitivity of Phf11b to DNA methylation dynamics and its impact on Phf11b activation. | ||||||
Thioridazine | 50-52-2 | sc-473180 | 50 mg | $500.00 | ||
Thioridazine activates Phf11b by influencing histone acetylation. Its impact on chromatin dynamics indirectly enhances Phf11b expression in the nucleus, revealing the intricate connection between thioridazine-mediated epigenetic modifications and the modulation of Phf11b activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D activates Phf11b through RNA polymerase inhibition, triggering a cellular response. The ensuing response indirectly upregulates Phf11b expression in the nucleus, highlighting the connection between transcriptional inhibition and the modulation of Phf11b activity. | ||||||