EAT2 Inhibitors
Chemical inhibitors of EAT2 can modulate the activity of this protein through various mechanisms by targeting specific kinases and signaling molecules that are part of its functional network. The inhibition of phosphoinositide 3-kinases (PI3K) by compounds such as Wortmannin and LY294002 can lead to a decrease in the PI3K-Akt signaling pathway, which is often utilized by proteins like EAT2 for transmitting cellular signals. Similarly, the specific inhibition of Src family tyrosine kinases by PP2 can disrupt EAT2's function if it is linked to Src kinase-mediated signaling cascades. Furthermore, Dasatinib, known for its broad spectrum kinase inhibition, including Src family kinases, can also be effective in inhibiting EAT2's activity by impeding the function of these kinases.
In addition to Src kinases, other signaling pathways are critical for the function of EAT2. The MAPK/ERK pathway, targeted by U0126, is a pivotal route for transmitting extracellular signals into intracellular responses, and the inhibition of this pathway can directly impact EAT2's activity. SB203580 and SP600125 respectively inhibit p38 MAPK and c-Jun N-terminal kinase (JNK), both of which can be essential for EAT2 signaling, leading to its functional inhibition. Moreover, LY3214996, which selectively targets ERK1/2, and ZM336372, which inhibits Raf kinase, can disrupt the MAPK pathway downstream of EAT2. Rapamycin, by inhibiting mTOR, can affect the mTOR signaling pathways that EAT2 may utilize for its function. Lastly, GF109203X targets protein kinase C (PKC), which, if involved in EAT2-dependent signaling, can suppress EAT2's role in cellular processes. Each of these inhibitors can directly or indirectly lead to the suppression of EAT2's activity by targeting specific molecules involved in its signaling pathways.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent phosphoinositide 3-kinase (PI3K) inhibitor. Given that EAT2 is known to be involved in signaling pathways that can include PI3K activity, inhibition of PI3K by Wortmannin can lead to a reduction in the downstream signaling required for EAT2's function, thereby functionally inhibiting EAT2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another well-characterized inhibitor of PI3K. By inhibiting PI3K, LY294002 can suppress the kinase activity that may be involved in the signaling pathways of EAT2, thus functionally inhibiting the protein. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. If EAT2 is part of a pathway involving Src kinase signaling, the inhibition of this kinase by PP2 would result in the functional inhibition of the EAT2 protein. | ||||||
PD 168393 | 194423-15-9 | sc-222138 | 1 mg | $162.00 | 4 | |
PD168393 is an irreversible inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. By inhibiting EGFR, this compound can decrease the tyrosine kinase activity that could be necessary for EAT2 downstream signaling, leading to its functional inhibition. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a broad spectrum protein tyrosine kinase inhibitor. It targets Src family kinases, which, if involved in EAT2-related pathways, would result in the functional inhibition of EAT2 due to the blockade of these critical signaling molecules. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of mitogen-activated protein kinase (MAPK/ERK), which is involved in a wide range of cellular processes. By inhibiting ERK signaling, U0126 can disrupt pathways that are crucial for the functional activity of EAT2. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibition of p38 MAPK can lead to a reduction in the signaling necessary for EAT2's function, thus functionally inhibiting EAT2. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). By preventing JNK signaling, SP600125 can interfere with pathways necessary for EAT2 function, resulting in its functional inhibition. | ||||||
LY3214996 | 1951483-29-6 | sc-507299 | 5 mg | $265.00 | ||
LY3214996 is a selective inhibitor of ERK1/2. If EAT2 is involved in ERK1/2 signaling, the inhibition of ERK1/2 would disrupt the necessary signaling for EAT2 function, leading to its functional inhibition. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $47.00 | 2 | |
ZM336372 is a potent inhibitor of Raf kinase. EAT2's function can be dependent on Raf kinase-mediated signaling, and thus, the inhibition of Raf by ZM336372 would result in the functional inhibition of EAT2. | ||||||