Dynlt3 Inhibitors
DYNLT3, a member of the dynein light chain family, plays a crucial role in the cytoplasmic dynein motor protein complex, involved in intracellular transport and various cellular processes. As a homodimer, DYNLT3 contributes to the binding of dynein to specific cargos, including the spindle checkpoint protein BUB3. Additionally, it functions independently as a transcriptional modulator, impacting gene expression.
The inhibition of DYNLT3 can be achieved through various indirect mechanisms, as highlighted by the diverse set of chemicals presented. These inhibitors target different cellular pathways and processes, affecting DYNLT3 expression and function. For instance, compounds like resveratrol and Wortmannin indirectly impact DYNLT3 through the modulation of the PI3K/AKT pathway, crucial for cell survival and proliferation. Other inhibitors, such as brefeldin A and Latrunculin A, disrupt vesicular transport and actin cytoskeleton dynamics, respectively, influencing the intracellular trafficking of DYNLT3. These diverse inhibitors offer a spectrum of strategies to investigate and manipulate DYNLT3 function, providing valuable insights into the intricate regulatory networks involving this dynein light chain. Further research is essential to unravel the precise molecular mechanisms underlying each inhibitor's impact on DYNLT3 and to elucidate discoveries in cellular processes and intracellular transport.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Polyphenolic compound known for its antioxidant properties. Inhibits DYNLT3 indirectly by modulating the SIRT1/FOXO3a pathway, leading to altered transcriptional regulation of DYNLT3. Resveratrol activates SIRT1, which deacetylates and activates FOXO3a, impacting DYNLT3 expression. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Fungal metabolite disrupting vesicular transport. Acts as an indirect inhibitor of DYNLT3 by perturbing the Golgi apparatus and secretory pathways. Disruption of these cellular processes affects the transport of proteins, potentially including DYNLT3, leading to reduced availability and function. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
HSP90 inhibitor affecting protein folding. Indirectly inhibits DYNLT3 by disrupting the chaperone function of HSP90, leading to proteasomal degradation of misfolded or unstable proteins, including DYNLT3. Geldanamycin-induced protein destabilization impacts the cellular pool of DYNLT3. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Cdc42 and Rac1 inhibitor affecting actin cytoskeleton. Acts indirectly on DYNLT3 by disrupting cytoskeletal dynamics, potentially influencing its intracellular trafficking. Alterations in cytoskeletal structure can affect the transport of molecular cargos, including DYNLT3, thereby impacting its availability and function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore impacting intracellular calcium levels. Indirectly inhibits DYNLT3 by modulating calcium-dependent signaling pathways. Changes in calcium concentrations influence cellular processes, potentially affecting DYNLT3 function, although the exact mechanism remains to be elucidated. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
Glucose analog and glycolytic inhibitor. Acts indirectly on DYNLT3 by disrupting energy metabolism. Altered glycolysis impacts cellular processes, potentially influencing DYNLT3 expression and function. The precise connection between glycolytic inhibition and DYNLT3 modulation requires further investigation. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Antimetabolite affecting nucleotide synthesis. Indirectly inhibits DYNLT3 by disrupting DNA replication and repair processes. Cellular responses to 5-fluorouracil-induced DNA damage may impact the expression or stability of DYNLT3, although the exact mechanism remains to be fully elucidated. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Actin polymerization inhibitor impacting cytoskeleton. Acts indirectly on DYNLT3 by disrupting cytoskeletal dynamics, potentially influencing its intracellular trafficking. Alterations in cytoskeletal structure can affect the transport of molecular cargos, including DYNLT3, thereby impacting its availability and function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor affecting the PI3K/AKT pathway. Indirectly inhibits DYNLT3 by modulating a signaling pathway crucial for cell survival and proliferation. Altered PI3K/AKT signaling may influence DYNLT3 expression or function, providing a potential indirect mechanism of inhibition. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
SERCA inhibitor impacting calcium homeostasis. Acts indirectly on DYNLT3 by disrupting intracellular calcium levels. Changes in calcium concentrations may influence cellular processes, potentially affecting DYNLT3 function, although the specific connection requires further exploration. | ||||||