Dvl-3 Activators
Common Dvl-3 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, SB-216763 CAS 280744-09-4, IWP-2 CAS 686770-61-6, Pyrvinium Pamoate CAS 3546-41-6 and Quercetin CAS 117-39-5.
Dvl-3, or Dishevelled-3, is a vital component of the Wnt signaling pathway, a complex network of proteins that play a central role in various cellular processes such as cell proliferation, differentiation, and migration. The Wnt signaling pathway has been extensively studied for its role in embryonic development and its implications in several diseases when dysregulated. Dvl-3, being a part of the Dishevelled protein family, acts as a signaling hub in the pathway, integrating signals from Wnt receptors to downstream effectors, thus modulating cellular responses. The importance of Dvl-3 lies in its ability to transduce extracellular Wnt signals into cellular responses, primarily by inhibiting the degradation of β-catenin, a key effector protein in the pathway. This leads to the accumulation and nuclear translocation of β-catenin, where it activates target gene transcription.
The chemical class of Dvl-3 Activators\ encompasses molecules that promote or enhance the activation or upregulation of the Dvl-3 protein. These activators may function through several mechanisms. Some might directly bind to Dvl-3, stabilizing its structure or promoting its interaction with other proteins in the Wnt signaling cascade. Others may facilitate post-translational modifications of Dvl-3, optimizing its function in the signaling pathway. Yet, some activators could indirectly boost Dvl-3 activity by inhibiting its negative regulators or enhancing its positive regulators. By amplifying the activity of Dvl-3, these activators can potentiate the Wnt signaling pathway, thereby influencing the myriad cellular processes it governs. Given the centrality of Dvl-3 in the Wnt signaling pathway, understanding the molecules that activate it can shed light on the intricate regulatory mechanisms governing cellular signaling and response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl inhibits GSK-3β, a kinase that targets β-catenin for degradation. By doing so, it can activate the Wnt signaling pathway, potentially inducing Dvl-3 expression. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
BIO inhibits GSK-3, leading to activation of the Wnt/β-catenin pathway. This might result in increased expression of Dvl-3. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $214.00 $326.00 $1275.00 | 1 | |
Wnt-C59 is a porcupine inhibitor that affects Wnt secretion. Altering Wnt signaling might indirectly affect Dvl-3 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate gene expression and cellular differentiation. It might influence Dvl-3 levels as part of its effects on cell fate and Wnt signaling. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
As a GSK-3 inhibitor, SB-216763 can activate Wnt signaling, potentially leading to increased Dvl-3 expression. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
IWP-2 inhibits porcupine, an enzyme required for Wnt secretion. Modulating Wnt signaling might indirectly affect Dvl-3 expression. | ||||||
SKL2001 | 909089-13-0 | sc-507410 | 10 mg | $123.00 | ||
SKL2001 directly activates β-catenin, potentially leading to modulation of the Wnt pathway and influencing Dvl-3 levels. | ||||||
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $228.00 $422.00 | ||
Pyrvinium targets Wnt signaling at the level of the axin complex. This might result in altered Dvl-3 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin has been reported to modulate Wnt signaling. It might influence Dvl-3 expression as part of its broader effects on cellular signaling. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $32.00 $86.00 $150.00 | 3 | |
Sulindac has been shown to affect Wnt signaling, potentially leading to changes in Dvl-3 levels. | ||||||