Dvl-3/Dishevelled 3/DVL3 Antibody (G-7): sc-271295

Dvl-3 Antibody (G-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dvl-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Dvl-3 monoclonal antibody (G-7) is raised against amino acids 606-665 mapping near the C-terminus of Dishevelled-3 of human origin. Anti-Dvl-3 antibody (G-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dvl-3 plays a crucial role in the Wnt signaling pathway, which is essential for various cellular processes, including cell proliferation, differentiation, and embryonic development. Dvl-3 protein is primarily located in the cytoplasm and is involved in the transduction of Wnt signals from the cell membrane to the nucleus, influencing gene expression. Anti-Dvl-3 antibody (G-7) is vital, as dysregulation of the Wnt pathway has been implicated in numerous diseases, including cancer and neurodegenerative disorders. Dvl-3 interacts with other key proteins in the Wnt signaling cascade, such as frizzled receptors and axin, highlighting its importance in maintaining cellular homeostasis and signaling integrity. Understanding Dvl-3 and its interactions can provide valuable insights into therapeutic targets for diseases associated with Wnt signaling dysregulation.

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Dvl-3/Dishevelled 3/DVL3 Antibody (G-7) References:

1. Dishevelled-1 and dishevelled-3 affect cell invasion mainly through canonical and noncanonical Wnt pathway, respectively, and associate with poor prognosis in nonsmall cell lung cancer.  |  Zhao, Y., et al. 2010. Mol Carcinog. 49: 760-70. PMID: 20572159
2. The dopamine D2 receptor regulates Akt and GSK-3 via Dvl-3.  |  Sutton, LP. and Rushlow, WJ. 2012. Int J Neuropsychopharmacol. 15: 965-79. PMID: 21777508
3. Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma.  |  Hegazy, SA., et al. 2013. Cell Signal. 25: 295-307. PMID: 23022960
4. Dysregulation of Wnt-Signaling and a Candidate Set of miRNAs Underlie the Effect of Metformin on Neural Crest Cell Development.  |  Banerjee, P., et al. 2016. Stem Cells. 34: 334-45. PMID: 26529121
5. ASPM promotes prostate cancer stemness and progression by augmenting Wnt-Dvl-3-β-catenin signaling.  |  Pai, VC., et al. 2019. Oncogene. 38: 1340-1353. PMID: 30266990
6. DVL1 and DVL3 differentially localize to CYP19A1 promoters and regulate aromatase mRNA in breast cancer cells.  |  Castro-Piedras, I., et al. 2018. Oncotarget. 9: 35639-35654. PMID: 30479694
7. Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain.  |  Pan, B. and Deng, C. 2019. Psychopharmacology (Berl). 236: 2687-2697. PMID: 31053935
8. cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.  |  Pizzuti, A., et al. 1996. Hum Mol Genet. 5: 953-8. PMID: 8817329

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dvl-3/Dishevelled 3/DVL3 Antibody (G-7) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-Dvl-3/Dishevelled 3/DVL3 Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dvl-3/Dishevelled 3/DVL3 Antibody (G-7) Specifications

Alternate Product Name: DVL3

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 606-665

Epitope Target: Dishevelled-3

Epitope Species: human

Product Reactivity/Detection: Dvl-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for Dvl-3/Dishevelled 3/DVL3 Antibody (G-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Dvl-3/Dishevelled 3/DVL3 antibody is Dvl-3/Dishevelled 3/DVL3 Antibody (4D3): sc-8027.