DUB2A Activators
DUB2A activators are a class of chemical compounds specifically designed to enhance the activity of the DUB2A gene or its associated deubiquitinating enzyme. DUB2A is part of the ubiquitin-specific protease (USP) family, which plays a crucial role in the regulation of protein degradation through the ubiquitin-proteasome system. The DUB2A enzyme functions by removing ubiquitin moieties from target proteins, thereby rescuing them from proteasomal degradation and altering their stability, localization, or function within the cell. Activators of DUB2A are designed to increase the enzymatic activity of DUB2A, thereby enhancing its ability to deubiquitinate specific substrates. This can lead to changes in the cellular levels of these target proteins, impacting various signaling pathways and cellular processes such as cell cycle regulation, DNA repair, and signal transduction.
The development of DUB2A activators involves a thorough understanding of the enzyme's structure, substrate specificity, and regulatory mechanisms. Researchers use techniques like X-ray crystallography, cryo-electron microscopy, and molecular docking studies to identify potential binding sites for activators on the DUB2A enzyme. High-throughput screening of chemical libraries is often employed to identify lead compounds that can effectively increase DUB2A activity. Once these compounds are identified, structure-activity relationship (SAR) studies are conducted to refine their chemical structures, optimizing factors such as binding affinity, specificity, and overall stability. These refinements may include modifying the core chemical scaffold or adding functional groups that enhance interactions with the enzyme. Additionally, factors such as solubility, cell permeability, and metabolic stability are carefully evaluated to ensure that the activators can function effectively in various biological systems. Through this detailed and systematic development process, DUB2A activators provide researchers with powerful tools to investigate the role of deubiquitination in cellular regulation, offering insights into the complex networks of protein homeostasis and the broader ubiquitin-proteasome system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor, specifically targeting HDAC1 and HDAC2. By inhibiting HDAC activity, it promotes hyperacetylation of histones, modulating chromatin structure. This epigenetic modulation positively influences Usp17ld expression and function, enhancing its thiol-dependent deubiquitinase activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Activates SIRT1, a NAD+-dependent deacetylase. SIRT1 deacetylates histones and non-histone proteins, impacting gene expression and cellular processes. Resveratrol-mediated SIRT1 activation indirectly up-regulates Usp17ld by modulating the acetylation status of proteins involved in the regulatory network linked to Usp17ld function and apoptotic processes. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Inhibits TGF-β type I receptor, suppressing TGF-β signaling. Usp17ld is predicted to be involved in the regulation of apoptotic processes, and TGF-β signaling can influence apoptotic pathways. SB-431542 indirectly activates Usp17ld by blocking TGF-β-mediated signals that negatively regulate apoptotic processes, thus promoting Usp17ld's role in apoptosis. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
HDAC inhibitor affecting class I and II HDACs. Promotes histone acetylation, leading to altered gene expression. By influencing the epigenetic landscape, sodium butyrate indirectly up-regulates Usp17ld, as changes in histone acetylation patterns impact the transcriptional regulation of genes involved in the apoptotic processes regulated by Usp17ld. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor, impacting the PI3K/Akt signaling pathway. Usp17ld's predicted localization in the endoplasmic reticulum membrane suggests its involvement in cellular signaling. LY294002, by inhibiting PI3K, indirectly activates Usp17ld through modulation of downstream signaling events, potentially influencing cellular processes and pathways linked to Usp17ld function and regulation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
Bromodomain inhibitor targeting BET proteins. By disrupting the interaction between BET proteins and acetylated histones, JQ1 influences the chromatin landscape. This epigenetic modulation indirectly up-regulates Usp17ld, as changes in chromatin structure impact the transcriptional regulation of genes involved in apoptotic processes and other cellular functions associated with Usp17ld. | ||||||
GSK1904529A | 1089283-49-7 | sc-507398 | 10 mg | $321.00 | ||
PI3K/mTOR inhibitor, affecting the PI3K/Akt/mTOR signaling pathway. Usp17ld's potential activity in the cytosol and nucleus implies involvement in intracellular signaling. GSK1904529A indirectly activates Usp17ld by modulating the PI3K/Akt/mTOR pathway, influencing downstream targets and cellular processes associated with Usp17ld function and regulation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor targeting the MAPK pathway. By blocking MEK, PD98059 influences the MAPK pathway, affecting downstream targets. Usp17ld may be indirectly activated as a result of altered MAPK signaling, impacting apoptotic processes and other cellular functions associated with Usp17ld. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
NF-κB inhibitor, impacting the NF-κB signaling pathway. Usp17ld's potential involvement in cellular regulation suggests a connection to NF-κB signaling. BAY 11-7082 indirectly up-regulates Usp17ld by suppressing NF-κB activation, influencing downstream targets and cellular processes associated with Usp17ld function and apoptotic regulation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor affecting the PI3K/Akt signaling pathway. Usp17ld's predicted localization in the endoplasmic reticulum membrane implies involvement in intracellular signaling. Wortmannin indirectly activates Usp17ld by inhibiting PI3K, thus modulating the PI3K/Akt pathway and impacting downstream targets and cellular processes associated with Usp17ld function and regulation. | ||||||