DRG11 Activators
DRG11 Activators refer to a series of chemical compounds that indirectly enhance the functional activity of DRG11, a protein presumably involved in neuronal development and function. These compounds influence various intracellular signaling pathways, which in turn can lead to the enhancement of DRG11 activity. For instance, Forskolin, Rolipram, PGE2, Retinoic Acid, Dibutyryl-cAMP, Caffeine, Vasoactive Intestinal Peptide, IBMX, PACAP, Sildenafil, and Zardaverine can all elevate intracellular cAMP levels. Increased cAMP is a pivotal messenger in many cellular processes, including those that govern neuron differentiation and synaptic plasticity, where DRG11 is likely to be active. By enhancing cAMP levels, these compounds indirectly promote DRG11's role in the development and maintenance of neuronal function.
Moreover, compounds such as Epibatidine impact synaptic transmission by acting as a nicotinic acetylcholine receptor agonist. This can lead to changes in neuroplasticity which, in turn, may enhance DRG11 activity in the complex network of neuronal signaling. Each of these compounds, through their unique interactions with cellular signaling pathways, has the potential to augment the functional activity of DRG11 in various neuronal contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing cAMP levels in cells. Elevated cAMP can activate protein kinase A (PKA), which in turn could enhance the functional activity of DJBP if DJBP is a substrate of PKA or is regulated by PKA-phosphorylated proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which could enhance the activity of DJBP by phosphorylation if DJBP is within the PKC signaling pathway. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 increases intracellular calcium levels, which could activate calcium-dependent proteins and potentially enhance the activity of DJBP if it is regulated by calcium signaling. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is a tyrosine phosphatase inhibitor, which can increase the phosphorylation state of proteins. This could enhance DJBP activity if it is regulated by tyrosine phosphorylation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, potentially enhancing DJBP activity through cAMP-dependent pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially enhancing the activity of DJBP if it interacts with calcium-binding proteins or is regulated by calcium-dependent kinases. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Db-cAMP is a cAMP analog that can activate PKA and could enhance DJBP activity if DJBP is a PKA substrate or is regulated by PKA-dependent signaling. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3), which could enhance DJBP activity if DJBP is regulated by GSK-3-mediated phosphorylation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate various signaling pathways, potentially enhancing DJBP activity if DJBP is regulated by any of these pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuins and can influence AMPK signaling, which could enhance DJBP activity if regulated through these pathways. | ||||||