DRAM2 Inhibitors
DRAM2 inhibitors are designed to target and modulate the activity of DRAM2, which is a protein encoded by the Damage-Regulated Autophagy Modulator 2 gene. DRAM2 is primarily associated with the autophagy process, a crucial cellular mechanism responsible for degrading and recycling damaged or unnecessary cellular components, including organelles and proteins. Autophagy plays a pivotal role in maintaining cellular homeostasis, and dysregulation of this process has been implicated in various diseases, including cancer and neurodegenerative disorders.
DRAM2 inhibitors encompasses a diverse array of compounds that possess the ability to interact with the DRAM2 protein and alter its function. These compounds are typically designed through rational drug design or high-throughput screening approaches, aiming to identify molecules that can selectively inhibit DRAM2's activity. The structural diversity of DRAM2 inhibitors allows researchers to explore various chemical scaffolds and optimize their properties for maximum efficacy and minimal off-target effects. By targeting DRAM2, these inhibitors aim to modulate autophagy levels, potentially leading to a better understanding of the autophagic process's role in different physiological and pathological conditions. This class of compounds represents a valuable tool for researchers in elucidating the intricate mechanisms of autophagy and exploring its implications in various cellular processes and diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
Inhibits autophagy by blocking the class III PI3K, which is upstream of DRAM2 in the initiation of autophagy. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Acts as a potent inhibitor of PI3K, thereby affecting the autophagic process in which DRAM2 is implicated. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Specifically targets and degrades Vps34 PI3K complexes, affecting the autophagy pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A broad-spectrum PI3K inhibitor that can disrupt autophagy at its initiation phase. | ||||||
SAR405 | 1523406-39-4 | sc-507416 | 1 mg | $125.00 | ||
A potent and specific inhibitor of Vps34, which can modulate the autophagy process involving DRAM2. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Inhibits V-ATPase, which is essential for the acidification of autophagosomes, indirectly affecting DRAM2. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Prevents autophagosome-lysosome fusion, which can influence the autophagic process DRAM2 is a part of. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Similar to chloroquine, it raises the pH of autophagosomes, affecting their fusion and DRAM2 function. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $62.00 | 8 | ||
Raises lysosomal pH and can thereby disrupt autophagy, indirectly impacting DRAM2's role. | ||||||
Lys05 | 1391426-24-6 | sc-507532 | 5 mg | $140.00 | ||
A derivative of chloroquine that can more potently block autophagy, potentially influencing DRAM2. | ||||||