DPEP2 Inhibitors
DPEP2 inhibitors function primarily by inhibiting key processes and pathways that DPEP2 is involved in. Valproic Acid, an inhibitor of histone deacetylases (HDACs), can potentially lead to the sequestration of DPEP2 in the nucleus, thereby decreasing its functional activityin the cytoplasm. On the other hand, Acivicin, a glutamine amidotransferase inhibitor, can decrease the availability of glutamine, a critical amino acid for DPEP2 activity. Similarly, Methotrexate, an inhibitor of dihydrofolate reductase (DHFR), indirectly affects DPEP2 function by inhibiting nucleotide synthesis which is crucial for DPEP2's role in peptide metabolism.
Other inhibitors such as Sulfasalazine, Isoniazid, Chloramphenicol, and Streptomycin influence DPEP2 indirectly by altering the immune response to bacterial infections. By suppressing the immune response or interfering with bacterial protein synthesis, these inhibitors can affect DPEP2's functional activity. Meanwhile, 3-Methyladenine, Bafilomycin A1, Chloroquine, Lys05, and Spautin-1 inhibit autophagy, a cellular process that DPEP2 may be involved in. These inhibitors block autophagy at different stages, thereby potentially decreasing the functional activity of DPEP2.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid is a known inhibitor of histone deacetylases (HDACs). By inhibiting HDACs, it promotes the acetylation of histones, which can affect the subcellular localization of DPEP2. It can potentially lead to the sequestration of DPEP2 in the nucleus, thereby decreasing its functional activity in the cytoplasm. | ||||||
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $104.00 $416.00 $655.00 $1301.00 | 10 | |
Acivicin is an inhibitor of glutamine amidotransferases. As DPEP2 catalyzes the hydrolysis of dipeptides and needs glutamine for its activity, inhibition of glutamine amidotransferases by Acivicin can decrease the availability of glutamine and subsequently the functional activity of DPEP2. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine is an inhibitor of NF-κB, a transcription factor that can regulate the expression of proteins involved in immune response. The inhibition of NF-κB can potentially alter the immune response and thereby indirectly affect the functional activity of DPEP2, which is known to play a role in immune regulation. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is an inhibitor of dihydrofolate reductase (DHFR) which plays a critical role in the synthesis of nucleotides. Given that DPEP2 is involved in peptide metabolism, which requires ATP (a type of nucleotide), inhibition of nucleotide synthesis can indirectly affect the functional activity of DPEP2. | ||||||
Isoniazid | 54-85-3 | sc-205722 sc-205722A sc-205722B | 5 g 50 g 100 g | $26.00 $101.00 $146.00 | ||
Isoniazid is an inhibitor of mycolic acid synthesis, which is crucial for the cell wall of mycobacteria. Inhibiting this process can indirectly decrease the functional activity of DPEP2, given its role in immune responses against bacterial infections. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Chloramphenicol inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit. As DPEP2 is involved in immune responses to bacterial infections, reducing bacterial protein synthesis can indirectly affect the functional activity of DPEP2. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine is an inhibitor of autophagy, a cellular process that DPEP2 may be involved in. By inhibiting autophagy, 3-Methyladenine can potentially decrease the functional activity of DPEP2. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the vacuolar type H+-ATPase (V-ATPase). V-ATPase is crucial for the acidification of vesicles, an essential step for autophagy. Inhibiting this process can indirectly reduce the functional activity of DPEP2, given its potential role in autophagy. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known to inhibit autophagy by raising the lysosomal pH, which may prevent the fusion of autophagosomes and lysosomes, leading to the accumulation of autophagosomes. As DPEP2 may be involved in autophagy, inhibiting this process can decrease the functional activity of DPEP2. | ||||||
Lys05 | 1391426-24-6 | sc-507532 | 5 mg | $140.00 | ||
Lys05 is a dimeric chloroquine that is more potent in blocking autophagy. By inhibiting autophagy, Lys05 can potentially decrease the functional activity of DPEP2, given its potential role in autophagy. | ||||||