Dnmt3L Activators
Dnmt3L activators include a range of chemicals that can indirectly influence the activity of Dnmt3L, a key player in epigenetic regulation through DNA methylation. These activators operate primarily by modulating the epigenetic landscape, either by influencing DNA methylation directly or by affecting related pathways and processes. For instance, compounds like 5-Azacytidine and Decitabine, known inhibitors of DNA methylation, can create an epigenetic context that necessitates the action of Dnmt3L, either through compensatory mechanisms or by altering the overall methylation landscape.
Similarly, nutrients and vitamins such as Vitamin C, Folic Acid, and B Vitamins, play a crucial role in one-carbon metabolism, which is essential for methyl group generation. These methyl groups are fundamental substrates for DNA methylation reactions. Therefore, the availability of these compounds can indirectly influence Dnmt3L activity by ensuring the availability of methylation substrates. Zinc, on the other hand, contributes to the structural integrity of many proteins and can thus impact the functional state of Dnmt3L.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
An inhibitor of DNA methyltransferases, 5-Azacytidine can alter the epigenetic state of cells, potentially affecting the expression or function of Dnmt3L. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2′-Deoxycytidine inhibits DNA methylation, potentially impacting Dnmt3L activity by altering the epigenetic environment. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Vitamin C can modulate the activity of ten-eleven translocation (TET) enzymes, influencing DNA demethylation processes that might affect Dnmt3L activity indirectly. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
As a methyl donor in methylation reactions, SAMe is crucial for DNA methylation processes and could influence Dnmt3L activity by affecting substrate availability. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, through its impact on gene expression, can modulate the expression of genes related to DNA methylation and potentially influence Dnmt3L activity. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
As a key molecule in one-carbon metabolism, Folic Acid is important for methyl group generation, which could indirectly influence Dnmt3L activity by affecting methylation substrates. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc plays a role in the structural integrity of many proteins and can influence DNA methylation processes, potentially impacting Dnmt3L activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can influence gene expression and has been shown to affect epigenetic mechanisms, potentially modulating Dnmt3L activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin influences various signaling pathways and gene expression patterns, including those related to DNA methylation, potentially impacting Dnmt3L activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a phytoestrogen, can modulate epigenetic mechanisms, including DNA methylation, potentially influencing Dnmt3L activity. | ||||||