The category of DNase II Activators encompasses a range of chemical compounds that, although not directly activating DNase II, can influence its activity indirectly through their effects on apoptosis and DNA damage pathways. DNase II is an enzyme that plays a critical role in DNA degradation during apoptosis, and the activation of this pathway often leads to an increase in DNase II activity. The first group of these compounds includes apoptosis-inducing agents such as Staurosporine, Camptothecin, Etoposide, Actinomycin D, and Cisplatin. These agents are known to induce DNA damage and trigger apoptotic pathways in cells, leading to the activation of various downstream enzymes including DNase II. For example, Staurosporine, a potent kinase inhibitor, and Camptothecin, a topoisomerase I inhibitor, induce apoptosis by disrupting key cellular processes, thereby potentially enhancing the activity of DNase II as part of the cellular response to apoptotic signals.
Another significant group comprises compounds that influence apoptosis through different mechanisms, including 5-Fluorouracil, Hydrogen Peroxide, Curcumin, Resveratrol, Sulforaphane, and Bortezomib. These substances can induce apoptosis through mechanisms such as oxidative stress, DNA damage, and inhibition of survival pathways, thereby potentially influencing the activity of DNase II. For instance, compounds like Hydrogen Peroxide and Sulforaphane induce oxidative stress, leading to apoptotic cell death and subsequent activation of DNA degradation pathways where DNase II plays a pivotal role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A kinase inhibitor that induces apoptosis, potentially enhancing DNase II activity in apoptotic DNA degradation. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
An inhibitor of topoisomerase I, inducing DNA damage and apoptosis, potentially upregulating DNase II. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
A topoisomerase II inhibitor, induces apoptosis and may influence DNase II activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Interferes with DNA replication and RNA synthesis, inducing apoptosis and potentially enhancing DNase II activity. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
A chemotherapy drug that induces DNA damage and apoptosis, possibly upregulating DNase II. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
An antimetabolite that induces apoptosis, potentially affecting DNase II activity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Induces oxidative stress, leading to apoptosis and potentially enhancing DNase II activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates apoptosis pathways, potentially influencing DNase II activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Influences apoptosis and DNA damage responses, potentially modulating DNase II activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Induces apoptosis through oxidative stress, potentially affecting DNase II. | ||||||