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DNase II Inhibitors

Deoxyribonucleases (DNases) are enzymes in the DNase family, specialized in cleaving DNA molecules. They are pivotal in various biological processes, including DNA repair, replication, recombination, and apoptosis. There are two main types: DNase I, which preferentially digests single-stranded DNA and is involved in apoptosis and clearing DNA from dying cells, and DNase II, which digests double-stranded DNA in acidic conditions like lysosomes. Their activity is essential for maintaining genomic integrity and regulating cellular processes involving controlled DNA degradation. DNases also play a role in the immune response by clearing extracellular DNA from pathogens and dead cells, thus stopping inflammation and autoimmunity. The regulation of DNase activity involves intricate signaling pathways and is meticulously controlled to avert unwarranted DNA damage. Targeting DNase deoxyribonucleases for disruption or inhibition using small molecules allows for a detailed understanding of their mechanistic functions. Inhibiting specific DNases enables researchers to observe the effects of hindered DNA degradation, revealing the roles of these enzymes in DNA repair, apoptosis, and immune response. This approach also clarifies how imbalances in DNase activity contribute to diseases, like autoimmune disorders, where abnormal DNA degradation plays a role. The use of inhibitors underscores the interaction between DNases and other cellular components, illustrating how these enzymes are integrated into broader cellular networks.

Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
Zinc	7440-66-6	sc-213177	100 g	$47.00		(0)
Zinc sulfate is an indirect inhibitor of DNaseII, as zinc ions influence cellular pathways related to DNA integrity. Zinc ions can modulate the activity of nucleases indirectly by affecting cellular processes, potentially leading to a reduction in the activity of DNaseII and preserving DNA integrity.
EGTA	67-42-5	sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D	1 g 10 g 100 g 250 g 1 kg	$20.00 $62.00 $116.00 $246.00 $799.00	23	(1)
EGTA is a calcium chelator that indirectly inhibits DNaseII by disrupting the calcium-dependent pathways associated with its activity. This indirect modulation impacts the enzymatic activity of DNaseII, potentially leading to the preservation of DNA integrity in cellular processes.
Pentoxifylline	6493-05-6	sc-203184	1 g	$20.00	3	(1)
Pentoxifylline is an indirect inhibitor of DNaseII through its modulation of cellular signaling pathways. It can influence pathways related to inflammation, potentially impacting DNaseII activity indirectly and preserving DNA integrity in the cellular context.
Diphenyleneiodonium chloride	4673-26-1	sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C	10 mg 25 mg 50 mg 100 mg 250 mg 500 mg	$148.00 $133.00 $311.00 $397.00 $925.00 $1801.00	24	(1)
DPI is an indirect inhibitor of DNaseII that acts by inhibiting NADPH oxidases, impacting cellular redox signaling pathways. This indirect modulation can influence the activity of DNaseII, potentially preserving DNA integrity by preventing excessive oxidative stress in cellular processes.
Sodium Butyrate	156-54-7	sc-202341 sc-202341B sc-202341A sc-202341C	250 mg 5 g 25 g 500 g	$30.00 $46.00 $82.00 $218.00	19	(3)
Sodium Butyrate is an indirect inhibitor of DNaseII through its modulation of histone acetylation and gene expression. This indirect modulation can impact the expression of DNaseII and potentially influence its activity, preserving DNA integrity in cellular processes.
3-Aminobenzamide	3544-24-9	sc-3501 sc-3501B sc-3501A	100 mg 1 g 5 g	$15.00 $36.00 $51.00	18	(1)
3-Aminobenzamide is an indirect inhibitor of DNaseII through its action as a poly(ADP-ribose) polymerase (PARP) inhibitor. This indirect modulation can influence cellular processes related to DNA repair and potentially impact the activity of DNaseII, preserving DNA integrity in the cellular context.
α-Amanitin	23109-05-9	sc-202440 sc-202440A	1 mg 5 mg	$260.00 $1029.00	26	(2)
α-Amanitin is a direct inhibitor of RNA polymerase II, indirectly influencing DNaseII activity by modulating transcription. This indirect modulation can impact the expression of DNaseII and potentially influence its activity, preserving DNA integrity in cellular processes.
Trolox	53188-07-1	sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D	500 mg 1 g 5 g 25 g 100 g	$37.00 $66.00 $230.00 $665.00 $1678.00	39	(1)
Trolox is an indirect inhibitor of DNaseII through its role as a vitamin E analog, influencing oxidative stress pathways. This indirect modulation can impact DNaseII activity, potentially preserving DNA integrity by preventing excessive oxidative damage in cellular processes.
Deferoxamine	70-51-9	sc-507390	5 mg	$250.00		(0)
Deferoxamine is an indirect inhibitor of DNaseII by chelating iron ions, influencing cellular iron homeostasis. This indirect modulation can impact pathways related to oxidative stress and DNaseII activity, potentially preserving DNA integrity in cellular processes.
Neocuproine	484-11-7	sc-257893 sc-257893A sc-257893B sc-257893C sc-257893D	1 g 5 g 25 g 100 g 250 g	$33.00 $88.00 $291.00 $1086.00 $2341.00	1	(1)
Neocuproine is an indirect inhibitor of DNaseII through its role as a copper chelator, influencing cellular copper homeostasis. This indirect modulation can impact pathways related to oxidative stress and DNaseII activity, potentially preserving DNA integrity in cellular processes.

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DNase II Inhibitors

Zinc

EGTA

Pentoxifylline

Diphenyleneiodonium chloride

Sodium Butyrate

3-Aminobenzamide

α-Amanitin

Trolox

Deferoxamine

Neocuproine