Molecular structure of Neocuproine, CAS Number: 484-11-7
Neocuproine (CAS 484-11-7)
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Alternate Names:
2,9-Dimethyl-1,10-phenanthroline; DMPHEN
Application:
Neocuproine is a phenanthroline based metal ion chelating agent
CAS Number:
484-11-7
Purity:
≥98%
Molecular Weight:
208.26
Molecular Formula:
C14H12N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Neocuproine preferentially chelates cuprous ions over ferrous ions and can be used for the spectrophotometric determination of copper. The Neocuproine-copper complex exists in a 2:1 ratio with a maximum absorption at 454 nm. Neocuproine is a phenanthroline compound that is used as a chelating agent in a wide array of transition metal-catalyzed reactions. It can also be used in the synthesis of aryl ketones.
Neocuproine (CAS 484-11-7) References
- Neocuproine potentiates the activity of the nitrergic neurotransmitter but inhibits that of S-nitrosothiols. | De Man, JG., et al. 1999. Eur J Pharmacol. 381: 151-9. PMID: 10554883
- Copper-mediated toxicity of 2,4,5-trichlorophenol: biphasic effect of the copper(I)-specific chelator neocuproine. | Zhu, BZ. and Chevion, M. 2000. Arch Biochem Biophys. 380: 267-73. PMID: 10933881
- Effect of neocuproine, a selective Cu(I) chelator, on nitrergic relaxations in the mouse corpus cavernosum. | Göçmen, C., et al. 2000. Eur J Pharmacol. 406: 293-300. PMID: 11020493
- Neocuproine inhibits the decomposition of endogenous S-nitrosothiol by ultraviolet irradiation in the mouse gastric fundus. | Ogülener, N. and Ergün, Y. 2004. Eur J Pharmacol. 485: 269-74. PMID: 14757150
- Effect of neocuproine, a copper(i) chelator, on rat bladder function. | Göçmen, C., et al. 2005. J Pharmacol Exp Ther. 312: 1138-43. PMID: 15501992
- Neocuproine, a copper (I) chelator, potentiates purinergic component of vas deferens contractions elicited by electrical field stimulation. | Göçmen, C., et al. 2005. Pharmacology. 75: 69-75. PMID: 16020948
- Neocuproine ablates melanocytes in adult zebrafish. | O'Reilly-Pol, T. and Johnson, SL. 2008. Zebrafish. 5: 257-64. PMID: 19133824
- Differential effect of neocuproine, a copper(I) chelator, on contractile activity in isolated ovariectomized non-pregnant rat, pregnant rat and pregnant human uterus. | Kumcu, EK., et al. 2009. Eur J Pharmacol. 605: 158-63. PMID: 19248249
- Production of LPS-induced inflammatory mediators in murine peritoneal macrophages: neocuproine as a broad inhibitor and ATP7A as a selective regulator. | Patel, OV., et al. 2013. Biometals. 26: 415-25. PMID: 23604539
- Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons. | Castro, PA., et al. 2014. Front Aging Neurosci. 6: 319. PMID: 25520655
- Synthesis and characterization of silibinin/phenanthroline/neocuproine copper(II) complexes for augmenting bone tissue regeneration: an in vitro analysis. | Rajalakshmi, S., et al. 2018. J Biol Inorg Chem. 23: 753-762. PMID: 29779062
- Protective effects of neocuproine copper chelator against oxidative damage in NSC34 cells. | Nunes, EA., et al. 2018. Mutat Res Genet Toxicol Environ Mutagen. 836: 62-71. PMID: 30442347
- Iron-Catalyzed Wacker-type Oxidation of Olefins at Room Temperature with 1,3-Diketones or Neocuproine as Ligands*. | Puls, F., et al. 2021. Angew Chem Int Ed Engl. 60: 14083-14090. PMID: 33856090
- Structural, Theoretical Investigations, Hirshfeld Surface Analysis, and Cytotoxicity Profile of a Neocuproine-Co(II)-Based Discrete Homodinuclear Complex. | Muslim, M., et al. 2023. Appl Biochem Biotechnol. 195: 871-888. PMID: 36219332
- Neocuproine, a selective Cu(I) chelator, and the relaxation of rat vascular smooth muscle by S-nitrosothiols. | Al-Sa'doni, HH., et al. 1997. Br J Pharmacol. 121: 1047-50. PMID: 9249237
Inhibitor of:
ATP7A, COA6, COPT2, CUTC, HAH1, MOXD2, SF4, and SLC39A12.Activator of:
COMMD10, COX19, CTR1, CUTC, FRP1, S-100A13, and SCO1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Neocuproine, 1 g | sc-257893 | 1 g | $33.00 | |||
Neocuproine, 5 g | sc-257893A | 5 g | $88.00 | |||
Neocuproine, 25 g | sc-257893B | 25 g | $291.00 | |||
Neocuproine, 100 g | sc-257893C | 100 g | $1086.00 | |||
Neocuproine, 250 g | sc-257893D | 250 g | $2341.00 |