DNAM-1 Activators
DNAM-1 Activators encompass a group of compounds that indirectly enhance the activity of DNAM-1, a protein crucial for the activation and function of natural killer (NK) cells and T cells in the immune system. These activators primarily operate by modulating immune-related signaling pathways or influencing the cellular environment in a manner that supports the function of DNAM-1. Compounds such as Phorbol 12-myristate 13-acetate (PMA) and Ionomycin are known to activate protein kinase C (PKC) and increase intracellular calcium levels, respectively. These actions synergize to activate T cells, which can, in turn, enhance DNAM-1 mediated signaling, crucial for the cytotoxic function of T cells and NK cells.
Additionally, natural compounds like Curcumin, Resveratrol, Epigallocatechin Gallate (EGCG), Quercetin, and Sulforaphane, known for their broad immunomodulatory effects, can indirectly influence DNAM-1 activity. These substances modulate various signaling pathways and immune responses, thereby potentially enhancing the function of DNAM-1 in immune cells. Nutrients such as Vitamin D3 and Zinc, essential for immune system functionality, also play a supportive role in enhancing DNAM-1 activity. Vitamin D3, through its immunomodulatory properties, and Zinc, as a critical element for immune cell function, contribute to optimizing the environment for DNAM-1 activation and function. Furthermore, Beta-glucans and Ginsenosides, recognized for their immune-boosting properties, could potentially augment DNAM-1 activity. These compounds, through their influence on immune cell activation and function, underscore the importance of indirect modulation of immune pathways to enhance the activity of critical immune proteins like DNAM-1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), which is involved in T cell activation and can enhance the function of DNAM-1 in immune response. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium, synergizing with PMA to activate T cells and potentially enhancing DNAM-1 mediated signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP levels, which can modulate T cell responses and potentially influence DNAM-1 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates various signaling pathways, including those in immune cells, and could potentially enhance DNAM-1 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Influences various signaling pathways and immune responses, potentially affecting DNAM-1 activity. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Modulates immune function and could enhance DNAM-1 activity in T cells and NK cells. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea, known for modulating immune responses, potentially influencing DNAM-1 activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Has immunomodulatory effects and could potentially enhance DNAM-1 mediated immune responses. | ||||||
Ginsenoside Rd | 52705-93-8 | sc-205706 sc-205706A | 1 mg 5 mg | $76.00 $190.00 | ||
Active components of ginseng, known for immunomodulatory effects, could potentially enhance DNAM-1 function. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, known for its effects on immune signaling, potentially affecting DNAM-1 activity. | ||||||