DnaJC10 Activators
DnaJC10 Activators belong to a distinctive chemical class that interacts with and modulates the activity of DnaJC10, a member of the heat shock protein (HSP) family. Heat shock proteins play crucial roles in cellular homeostasis and stress response by aiding in the correct folding of proteins, preventing protein aggregation, and facilitating protein transport across cellular membranes. DnaJC10, specifically, is a co-chaperone protein that collaborates with HSP70 to regulate protein folding within the endoplasmic reticulum (ER). This dynamic partnership is essential for maintaining cellular proteostasis and ensuring the proper functioning of various cellular processes.
The small molecules categorized as DnaJC10 Activators exhibit a specific affinity for DnaJC10, inducing conformational changes that enhance its chaperone activity. By doing so, these activators contribute to the stabilization of protein structures within the ER, thereby promoting efficient protein maturation and trafficking. This modulation of DnaJC10 function is particularly relevant in cellular environments undergoing heightened stress, where protein folding demands are increased. The identification and characterization of DnaJC10 Activators provide valuable insights into the intricate network of molecular interactions that govern cellular proteostasis.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to induce the expression of endoplasmic reticulum (ER) stress proteins, including DnaJC10. Curcumin enhances the activity of DnaJC10 by upregulating the unfolded protein response (UPR) pathway, in which DnaJC10 is a critical player. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to upregulate the UPR pathway, thereby indirectly enhancing the activity of DnaJC10. It does this by promoting the accumulation of misfolded proteins in the ER, which in turn triggers the UPR pathway. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
TUDCA is a bile acid that has been shown to enhance ER stress response pathways, including the UPR pathway. It enhances the activity of DnaJC10 by reducing the accumulation of misfolded proteins in the ER. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Salubrinal inhibits dephosphorylation of eIF2α, thereby enhancing the UPR pathway and indirectly enhancing the activity of DnaJC10. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $100.00 $459.00 $816.00 $4080.00 $7140.00 | 2 | |
Guanabenz selectively enhances the PERK-eIF2α branch of the UPR pathway, thereby indirectly enhancing the activity of DnaJC10. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin induces ER stress by inhibiting the SERCA pump, thereby leading to calcium depletion in the ER and the triggering of the UPR pathway, indirectly enhancing DnaJC10 activity. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, leading to the accumulation of misfolded proteins in the ER and induction of the UPR pathway, thereby indirectly enhancing DnaJC10 activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that leads to the accumulation of misfolded proteins in the ER, thereby inducing the UPR pathway and indirectly enhancing DnaJC10 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG has been shown to induce the UPR pathway by disrupting ER calcium homeostasis, thereby indirectly enhancing DnaJC10 activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that induces the UPR pathway by leading to the accumulation of misfolded proteins in the ER, thereby indirectly enhancing DnaJC10 activity. | ||||||