DNA pol ε ss Activators
DNA Polymerase epsilon (DNA Pol ε) is a critical eukaryotic enzyme involved in DNA replication and repair. It's a multi-subunit complex that takes part in the synthesis of leading and lagging strands during replication, as well as in DNA mismatch repair. While there isn't a formally recognized class of chemicals called "DNA Pol ε ss Activators," the enzyme's role in cellular function has led researchers to investigate various compounds that might influence its activity or expression. One key point of investigation centers around the natural compounds like resveratrol and curcumin. Resveratrol, a polyphenolic compound found in grapes, has been studied for its ability to activate cellular stress-response genes, which could potentially extend to the upregulation of DNA Pol ε. Curcumin, found in turmeric, has a similar story; it has been demonstrated to modulate cellular pathways tied to DNA repair and might therefore affect DNA Pol ε. These natural compounds are not acting in isolation but are part of a complex network of cellular reactions.
Other chemical classes, like alkaloids and flavonoids, are also under investigation for similar reasons. For example, berberine-an alkaloid-has effects on cellular regulatory pathways, which may indirectly involve DNA Pol ε. On the synthetic side, certain small-molecule inhibitors and activators have been studied for their ability to modulate DNA Pol ε activity, often as a part of broader cellular responses to DNA damage or replication stress. The compounds potentially affecting DNA Pol ε usually do so as part of a multi-faceted response to cellular events such as stress or damage. Their mechanisms might range from transcriptional regulation to direct enzymatic modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in grapes and wine. It has been observed to induce various cellular stress-response genes. While not directly proven, it may potentially upregulate DNA Pol ε as part of a broader cellular stress response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound in turmeric, has been shown to activate various cellular pathways related to DNA repair and replication. It is plausible that curcumin could induce DNA Pol ε expression as part of these repair mechanisms. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid found in fruits and vegetables. It has been implicated in the activation of cellular repair pathways, possibly impacting DNA Pol ε expression indirectly via these pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, sulforaphane has been shown to induce phase 2 detoxification enzymes and could potentially induce DNA Pol ε as part of a broader cellular protective mechanism. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone found in soy, has been shown to modulate cellular pathways related to DNA repair. Its potential to induce DNA Pol ε could be an extension of its role in these pathways. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is known to modulate several cellular pathways including those involved in DNA repair. It may potentially influence the expression of DNA Pol ε in this context. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) is a catechin found in green tea. It has been studied for its role in cellular stress response pathways, which could potentially include the induction of DNA Pol ε. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is an alkaloid found in various plants and has been noted for its effects on cellular regulatory pathways, which may include the potential to induce DNA Pol ε expression. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
Fisetin is a flavonoid with known antioxidant properties. It has been shown to influence DNA repair pathways, making it possible that it could induce DNA Pol ε expression. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Found in cruciferous vegetables, indole-3-carbinol has been studied for its effects on cellular detoxification pathways. It might also have a role in inducing DNA Pol ε as part of these mechanisms. | ||||||