Date published: 2025-12-11

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Desmoplakin Inhibitors

Desmoplakin inhibitors are a class of chemical compounds that specifically target and modulate the function of desmoplakin, a crucial protein found in the desmosomes of animal cells. Desmosomes are specialized cell junctions responsible for providing structural integrity and strength to tissues subjected to mechanical stress, such as the skin, heart muscle, and epithelial tissues. Desmoplakin is a key component of these desmosomal junctions, as it plays a central role in anchoring intermediate filaments to the cell membrane. This interaction ensures the stable cohesion of adjacent cells and provides the tissue with resilience against mechanical forces, making it essential for the maintenance of tissue integrity and overall structural stability. Desmoplakin inhibitors are designed to interfere with the normal functioning of desmoplakin by binding to it or disrupting its interactions with other cellular components. By doing so, these inhibitors have the potential to weaken the adhesion between cells in tissues, thereby influencing various physiological processes. While research into desmoplakin inhibitors is ongoing and their precise mechanisms may vary, they represent a promising area of study for understanding cell-cell adhesion and its role in diseases like pemphigus vulgaris and arrhythmogenic cardiomyopathy, where desmosomal dysfunction is implicated.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

This compound is a cytidine analog, which can incorporate into DNA and RNA. It is known to cause DNA demethylation, potentially affecting the transcription of various genes including those encoding for proteins like desmoplakin.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Trichostatin A is a histone deacetylase inhibitor. By altering histone acetylation, it can change the chromatin structure and subsequently influence gene expression. This may lead to the modulation of desmoplakin expression.

Valproic Acid

99-66-1sc-213144
10 g
$85.00
9
(1)

Similar to Trichostatin A, Valproic Acid is a histone deacetylase inhibitor. It can change the acetylation status of histones, potentially influencing the expression of various genes including those coding for desmoplakin.

Fluorouracil

51-21-8sc-29060
sc-29060A
1 g
5 g
$36.00
$149.00
11
(1)

5-Fluorouracil is a pyrimidine analog that interferes with DNA synthesis. It could potentially affect the transcription and translation processes of various proteins, including desmoplakin, though its effect on desmoplakin expression specifically would depend on the cellular context.

Methotrexate

59-05-2sc-3507
sc-3507A
100 mg
500 mg
$92.00
$209.00
33
(5)

Methotrexate inhibits dihydrofolate reductase, affecting DNA synthesis and repair, as well as cellular replication. This could lead to changes in the expression of various proteins, potentially including desmoplakin.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

EGCG, a major component of green tea, has been shown to influence gene expression and protein synthesis. Its potential effects on desmoplakin expression would depend on the specific cellular context and signaling pathways involved.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin, from turmeric, has multiple cellular effects, including influencing gene expression. Its potential to modulate the expression of desmoplakin would depend on the cell type and specific signaling pathways engaged.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol, found in grapes and berries, has been shown to influence various signaling pathways and gene expression profiles. Its effects on desmoplakin expression would be context-dependent.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic Acid, a derivative of vitamin A, influences cell differentiation and gene expression. It has the potential to modulate the expression of various proteins, including desmoplakin, depending on the cellular environment.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin inhibits the mTOR pathway, affecting cell growth and protein synthesis. Its influence on desmoplakin expression would depend on the specific cellular context and the signaling pathways involved.