Desmin Inhibitors
Desmin inhibitors belong to a specific class of compounds designed to selectively target the protein desmin, an intermediate filament protein primarily found in muscle cells, particularly in smooth, skeletal, and cardiac muscle tissues. Desmin plays a critical role in maintaining the structural integrity and function of muscle cells by providing mechanical support and organizing the cytoskeleton. It forms networks within the cells, linking the contractile elements and organelles, contributing to the stability and proper functioning of muscle tissue. Desmin inhibitors are meticulously designed molecules engineered to interfere with the function or assembly of desmin filaments, disrupting its role in maintaining the cytoskeletal architecture within muscle cells.
Chemically, desmin inhibitors are developed to selectively bind to specific regions or functional domains of the desmin protein, aiming to disrupt its polymerization into filaments or interfere with its interactions with other cellular components. The molecular structure of these inhibitors is intricately designed to fit into the binding sites or active regions of desmin, preventing its proper assembly into filaments or compromising its ability to maintain the structural framework of muscle cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-FU can inhibit DNA synthesis. It might affect various cellular pathways, potentially down-regulating Desmin expression in certain muscle-related cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a corticosteroid, might modulate muscle cell differentiation and subsequently down-regulate Desmin expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Tretinoin can affect muscle cell differentiation. It might directly or indirectly down-regulate Desmin expression in muscle-related contexts. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR signaling, which can influence protein synthesis in muscle cells and might down-regulate Desmin. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, might affect DNA replication and transcription, potentially down-regulating Desmin in certain contexts. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib, a proteasome inhibitor, can affect protein turnover. It might influence Desmin stability and down-regulate its expression. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen, primarily an anti-estrogen agent, can have off-target effects on muscle cells. It might down-regulate Desmin under specific conditions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is an HDAC inhibitor. By affecting chromatin structure and gene transcription, it might down-regulate Desmin expression in muscle cells. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC, an antioxidant, might modulate redox-sensitive signaling pathways, potentially down-regulating Desmin in certain conditions. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $61.00 | 17 | |
Mifepristone, a glucocorticoid receptor antagonist, could affect muscle cell physiology and potentially down-regulate Desmin. | ||||||