DDX10 Inhibitors
Chemical inhibitors of DDX10 utilize diverse mechanisms to inhibit the helicase activity of this protein. Novobiocin targets the ATPase domain of DDX10, obstructing ATP binding and subsequent helicase activity. Suramin, by interacting with nucleotides and nucleic acids, can inhibit DDX10 by disrupting the enzyme's ability to hydrolyze ATP. Aurintricarboxylic Acid inhibits the interaction between DDX10 and its RNA substrate by binding to the nucleic acid binding sites on DDX10, effectively incapacitating the protein's functional interaction with RNA.
Ethidium Bromide, Berberine, Amsacrine, Daunorubicin, Mitoxantrone, and Actinomycin D all act by interfering with the nucleic acids that DDX10 is meant to engage with. Ethidium Bromide and Berberine intercalate into nucleic acids and alter the structure of RNA or DNA, which hinders DDX10 from binding or unwinding its substrate. This structural alteration of the nucleic acids by intercalating agents presents a barrier to DDX10's helicase activity. Oxaliplatin forms DNA adducts, creating crosslinks within the DNA that are insurmountable by the helicase function of DDX10, thus inhibiting its activity. Actinomycin D binds to DNA and blocks the transcription and interaction sites, making them inaccessible to DDX10, precluding the unwinding action of the helicase. Heparin, though primarily known for its anticoagulant properties, also possesses the ability to bind to proteins that interact with nucleic acids; it can bind to DDX10 and sterically hinder the protein from engaging with its nucleic acid substrates, thus inhibiting the helicase activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $32.00 $48.00 $94.00 | 13 | |
Aurintricarboxylic Acid acts as an inhibitor of nucleic acid-protein interactions. By binding to the nucleic acid binding sites, it can prevent DDX10 from interacting with its RNA substrate, thereby inhibiting its function. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $48.00 $150.00 $588.00 $2086.00 | 12 | |
Ethidium Bromide intercalates into double-stranded nucleic acids and may inhibit DDX10 by altering the structure of the RNA it interacts with, thereby obstructing the helicase from properly binding or unwinding RNA. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Heparin is known to inhibit nucleic acid-binding proteins. It can bind to DDX10, preventing the protein from interacting with nucleic acids, which is essential for its helicase activity. | ||||||
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $128.00 $380.00 | ||
Novobiocin acts as an inhibitor of ATP-binding proteins. It could bind to the ATPase domain of DDX10, blocking ATP binding, and therefore, inhibiting the enzyme's helicase activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is known to intercalate into DNA and can inhibit DDX10 by stabilizing the structure of DNA or RNA, making it less accessible for unwinding or modification by the helicase. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin inhibits various enzymes that interact with nucleotides and nucleic acids. It can inhibit DDX10 by blocking its interaction with RNA or disrupting the enzyme's ability to hydrolyze ATP, which is necessary for helicase activity. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $112.00 $394.00 | 8 | |
Oxaliplatin forms DNA adducts and could inhibit DDX10 by crosslinking the DNA, thereby preventing the helicase from accessing or unwinding the nucleic acid substrate. | ||||||
Daunorubicin hydrochloride | 23541-50-6 | sc-200921 sc-200921A sc-200921B sc-200921C | 10 mg 50 mg 250 mg 1 g | $105.00 $438.00 $837.00 $1569.00 | 4 | |
Daunorubicin intercalates into DNA and can inhibit DDX10 by blocking the enzyme's access to its nucleic acid substrate or by altering the substrate's structure, hindering the unwinding process. | ||||||
Amsacrine hydrochloride | 54301-15-4 | sc-214540 | 10 mg | $232.00 | ||
Amsacrine intercalates into DNA and can inhibit DDX10 by changing the DNA structure, which is required for the helicase to bind and unwind the nucleic acid effectively. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Mitoxantrone intercalates into DNA and RNA and can inhibit DDX10 by interfering with the helicase's ability to interact with its nucleic acid substrate, thus preventing the unwinding of the substrate. | ||||||