DDX10 Activators

DDX10 Activators comprise a diverse group of chemical compounds that directly or indirectly enhance the functional activity of DDX10, a crucial RNA helicase involved in RNA processing. These compounds act through various mechanisms to promote the efficient unwinding and processing of RNA substrates by DDX10. Quercetin, for example, directly binds to DDX10, facilitating RNA unwinding and efficient RNA processing. ATP serves as a co-factor that directly activates DDX10 by providing the necessary energy for RNA unwinding. N6-methyladenosine (m6A) modifies RNA substrates to make them more susceptible to DDX10-mediated unwinding and processing.

Indirect activators like caffeine inhibit adenosine receptors, preventing the inhibition of DDX10 activity and promoting RNA processing. RNA Pol II inhibitors, such as α-amanitin, redirect DDX10 from transcription tasks to RNA processing by reducing RNA Pol II-mediated transcription. Guanosine enhances DDX10 activity by facilitating its interaction with specific RNA substrates. Sam68 inhibitors prevent the inhibition of DDX10 by Sam68, allowing DDX10 to carry out its RNA unwinding and processing functions. Phenanthroline promotes efficient RNA unwinding and processing by facilitating the binding of DDX10 to RNA substrates. Poly(A) binding protein inhibitors prevent poly(A) binding protein from interfering with RNA processing by DDX10. Adenosine deaminase inhibitors maintain the availability of adenosine, which is essential for ATP synthesis and DDX10 activation.