DCAF16 Activators
DCAF16 Activators are a category of chemical compounds that interact specifically with the protein known as DDB1 and CUL4 associated factor 16 (DCAF16). The intricate biological role of DCAF16 lies within the ubiquitin-proteasome system, a critical pathway responsible for protein degradation and turnover within the cell. This system is essential for maintaining cellular homeostasis, regulating protein levels, and ensuring the timely removal of damaged or misfolded proteins. DCAF16 serves as a substrate recognition component in the CUL4-DDB1 ubiquitin ligase complex, which is pivotal in marking specific proteins for degradation by attaching ubiquitin molecules to them. Activators of DCAF16 can modulate this process by enhancing the ability of DCAF16 to identify and bind its target substrates, thereby affecting the ubiquitination and subsequent proteasomal degradation of these proteins.
The engagement of DCAF16 Activators with the ubiquitin-proteasome pathway elucidates their influence on cellular mechanisms at a molecular level. By altering the efficiency of substrate recognition by DCAF16, these activators can impact a variety of cellular processes including, but not limited to, cell cycle progression, DNA damage response, and signal transduction pathways. The effects of modulating such a fundamental pathway are far-reaching, influencing the proteomic landscape of the cell and potentially altering the function or stability of numerous proteins. The specificity and binding affinity of DCAF16 Activators to their target is of great interest in biochemistry and molecular biology, as these compounds can serve as tools to dissect the nuances of protein degradation pathways and to unravel the complex network of protein interactions that govern cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an adenylate cyclase activator that increases cAMP levels in cells, thereby activating PKA. PKA can phosphorylate a plethora of proteins, leading to the enhancement of DCAF16's function in ubiquitin-mediated proteolysis. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to their accumulation. The increased levels of these cyclic nucleotides can amplify the PKA pathway, potentially enhancing DCAF16's role in protein ubiquitination. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a potent antioxidant that has been shown to inhibit various protein kinases. By modifying kinase activity, EGCG could potentiate DCAF16's function by influencing the substrate specificity or activity of the CUL4-DDB1 E3 ubiquitin ligase complex, to which DCAF16 is a substrate receptor. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins. By inhibiting the proteasome, MG-132 could indirectly increase the substrate availability for DCAF16, thereby enhancing its functional activity in protein ubiquitination. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB-216763 is a GSK-3 inhibitor that can upregulate β-catenin. Increased β-catenin levels might interact with the ubiquitin-proteasome system in which DCAF16 functions, thereby potentially enhancing its role in this process. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a specific inhibitor of the proteasome. Similar to MG-132, by inhibiting proteasome activity, Lactacystin could lead to an increase in DCAF16 substrates, thus enhancing the functional activity of DCAF16. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a PKC activator, which can modulate various signaling pathways including those involved in protein ubiquitination. Activation of PKC could influence the activity or expression of proteins that interact with DCAF16, thus enhancing its functional role. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a MEK inhibitor, which could lead to alterations in the MAPK pathway. By modulating this pathway, U0126 may enhance DCAF16 activity indirectly by affecting proteins that are part of the ubiquitination cascade that DCAF16 regulates. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is a MEK inhibitor similar to U0126, that can alter MAPK pathway signaling. Through this alteration, DCAF16's function in protein ubiquitination could be indirectly enhanced as the pathway affects multiple proteins that are substrates for ubiquitination. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, which can lead to an increase in phosphorylated proteins. This increase may enhance the ubiquitination process in which DCAF16 is involved as a substrate receptor. | ||||||