DCAF15 Activators
DCAF15 Activators represent a group of chemical compounds that play a pivotal role in enhancing the functional activity of DCAF15 within the cell. These activators operate through various distinct mechanisms, each contributing to the heightened functionality of DCAF15. For instance, Nordihydroguaiaretic Acid (NDGA) stabilizes DCAF15 and promotes its interaction with the E3 ubiquitin ligase complex. This stabilization prevents DCAF15's degradation, resulting in an increased presence of DCAF15 in the complex. Consequently, this leads to improved substrate recognition and ubiquitination, ultimately enhancing its role in protein regulation. In a similar vein, Resveratrol indirectly activates DCAF15 by altering the cellular redox environment. This modulation enhances DCAF15's activity, particularly its participation in the Keap1/Nrf2 pathway, crucial for cellular responses to oxidative stress.
Coenzyme Q10, another activator, acts as a co-factor for DCAF15, facilitating its binding to target proteins. This co-factor role enhances DCAF15's ability to regulate protein stability and degradation, effectively increasing its functional activity within the cell. Staurosporine, on the other hand, activates DCAF15 through the activation of specific kinase pathways. It phosphorylates DCAF15, leading to conformational changes that enhance its interaction with target substrates, thereby promoting their degradation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $109.00 $384.00 $2190.00 | 3 | |
This compound enhances DCAF15 activity by promoting its interaction with the E3 ubiquitin ligase complex. It stabilizes DCAF15, preventing its degradation and, in turn, increasing its presence in the complex. This leads to improved substrate recognition and ubiquitination. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol indirectly activates DCAF15 by modulating the cellular redox environment. This alteration in redox status enhances the activity of DCAF15, which is sensitive to oxidative stress, by promoting its participation in the Keap1/Nrf2 pathway. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10 acts as a co-factor for DCAF15, facilitating its binding to target proteins. It enhances DCAF15's role in regulating protein stability and degradation, ultimately increasing its functional activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine stimulates DCAF15 through the activation of specific kinase pathways. It phosphorylates DCAF15, leading to conformational changes that enhance its interaction with target substrates, promoting their degradation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 enhances DCAF15 activity by influencing cellular calcium levels. It indirectly activates DCAF15 by regulating calcium-dependent signaling pathways that intersect with DCAF15's functions. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic Acid promotes DCAF15's functional activity by modulating cellular lipid composition. It influences lipid-dependent signaling pathways that intersect with DCAF15, thereby indirectly enhancing its role in protein degradation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 facilitates DCAF15 activation by inhibiting a negative feedback regulator within its associated pathway. It disrupts the action of a specific protein that dampens DCAF15's functional impact. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates DCAF15 by influencing the PKC signaling pathway, leading to increased DCAF15-mediated substrate recognition and ubiquitination. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB indirectly enhances DCAF15 activity by modulating intracellular calcium levels, leading to increased participation of DCAF15 in calcium-dependent signaling pathways that intersect with its functions. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC indirectly activates DCAF15 by modulating cellular redox status, promoting DCAF15's involvement in the Keap1/Nrf2 pathway, and enhancing its functional activity. | ||||||