DAPL1 Inhibitors
Chemical inhibitors of DAPL1 include a range of compounds that target various signaling pathways and molecular processes. Staurosporine, a potent protein kinase inhibitor, can obstruct the phosphorylation events essential for DAPL1's activity. By suppressing kinases within DAPL1's operational pathways, staurosporine can impede the functional activity of DAPL1. Similarly, Wortmannin and LY294002, both phosphoinositide 3-kinase (PI3K) inhibitors, work by blocking the PI3K/Akt signaling pathway. Since PI3K/Akt is a common modulatory pathway for numerous proteins, the inhibition by these compounds can lead to a downstream reduction in DAPL1 activity. U0126 and PD98059, which specifically target MEK1/2, prevent the activation of the ERK pathway-a pathway that, when inhibited, can lead to the functional inhibition of DAPL1.
Additionally, SP600125 and SB203580 target the c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. SP600125 can inhibit DAPL1, while SB203580 can inhibit DAPL1 by obstructing the p38 MAPK pathway, which may regulate or interact with DAPL1. Go6983 and GF109203X, both protein kinase C (PKC) inhibitors, can inhibit DAPL1. PP2, an inhibitor of Src family kinases, can inhibit DAPL1 by blocking pathways that involve Src kinase signaling. Lastly, Y-27632, which inhibits the Rho-associated protein kinase (ROCK), can lead to the inhibition of DAPL1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. DAPL1's function is predicated on specific phosphorylation events, and by inhibiting kinases that phosphorylate proteins within the same pathway, staurosporine can impede DAPL1's functional activity. | ||||||
BAPTA, Free Acid | 85233-19-8 | sc-201508 sc-201508A | 100 mg 500 mg | $67.00 $262.00 | 10 | |
BAPTA is a calcium chelator, and by sequestering calcium, it can inhibit calcium-dependent proteins. If DAPL1 requires calcium for its activity, BAPTA can functionally inhibit DAPL1 by depleting available calcium. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of phosphoinositide 3-kinases (PI3K). By blocking PI3K, it affects the downstream Akt signaling pathway, which may be crucial for DAPL1's activity, leading to functional inhibition of DAPL1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor, similar to wortmannin, and can inhibit the PI3K/Akt pathway, thus indirectly inhibiting DAPL1 if it is part of this signaling cascade. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that prevents the activation of ERK1/2. If DAPL1 is regulated by the ERK pathway, PD98059 can inhibit its activity by preventing activation of the pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). It can functionally inhibit DAPL1 if DAPL1's activity is modulated by JNK signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. If DAPL1 is part of the p38 MAPK pathway or is regulated by it, inhibition by SB203580 would impede DAPL1's function. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a broad-spectrum protein kinase C (PKC) inhibitor. DAPL1 can be inhibited by Go6983 if it is activated by PKC or is part of a pathway that includes PKC-dependent signaling. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X is another PKC inhibitor. If DAPL1's activity is contingent upon PKC signaling, GF109203X can inhibit this signaling, leading to a decrease in DAPL1 activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family kinases. If DAPL1 operates within a pathway that involves Src kinase signaling, PP2 could functionally inhibit DAPL1 by blocking this pathway. | ||||||