DAPL1 Activators
DAPL1 Activators predominantly function by enhancing the ERK pathway, which DAPL1 is a part of. Compounds such as Curcumin, Genistein, FR180204, PD184352, Forskolin, Epigallocatechin gallate, and Quercetin all can indirectly lead to the activation of DAPL1 through this pathway. These compounds act on different components of the ERK pathway, either by activating the pathway directly or by inhibiting negative regulators of the pathway, ultimately leading to enhanced DAPL1 functional activity.
The individual compounds exert their effects on the ERK pathway through distinct mechanisms. For instance, Curcumin can directly activate the ERK pathway. Quercetin inhibits PI3K, another negative regulator of the ERK pathway, thereby enhancing DAPL1 activity. Genistein and Epigallocatechin gallate inhibit protein tyrosine kinases that negatively regulate the ERK pathway, thereby enhancing DAPL1 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can activate the ERK pathway. DAPL1 is known to be downstream of the ERK pathway, so stimulation of this pathway by Curcumin can lead to its activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein inhibits protein tyrosine kinases, which can negatively regulate the ERK pathway. By inhibiting these kinases, Genistein can enhance the functional activity of DAPL1 through the ERK pathway. | ||||||
ERK Inhibitor II, FR180204 | 865362-74-9 | sc-203945 sc-203945A sc-203945B sc-203945C | 1 mg 5 mg 10 mg 50 mg | $108.00 $162.00 $234.00 $924.00 | 45 | |
FR180204 is an ERK inhibitor. However, at non-inhibitory concentrations, it can indirectly activate DAPL1, which is downstream in the ERK pathway. | ||||||
PD 184,352 | 212631-79-3 | sc-202759 sc-202759A | 1 mg 5 mg | $39.00 $255.00 | 34 | |
PD184352 is a selective MEK1/2 inhibitor. By inhibiting MEK1/2, PD184352 can indirectly lead to activation of DAPL1, which is downstream in this pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. This can enhance the ERK pathway, indirectly leading to the activation of DAPL1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate can inhibit certain protein tyrosine kinases that negatively regulate the ERK pathway. By inhibiting these kinases, it can enhance the functional activity of DAPL1 through the ERK pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin inhibits PI3K, which negatively regulates the ERK pathway. By inhibiting PI3K, Quercetin can enhance the functional activity of DAPL1 through the ERK pathway. | ||||||