D630042P16Rik Activators
Ssu2, a homolog of ssu-2, is implicated in odontogenesis and possesses predicted functions in heat shock protein and unfolded protein binding activities. The regulation of Ssu2's activity is critical for its involvement in these cellular processes. Here, we explore potential chemical activators that can modulate Ssu2, focusing on unfolded protein binding and heat shock protein interactions. Geldanamycin and 17-AAG, both Hsp90 inhibitors, indirectly activate Ssu2 by influencing heat shock protein binding. Thapsigargin, a SERCA inhibitor, indirectly activates Ssu2 by modulating calcium levels, affecting unfolded protein binding during odontogenesis. BAPTA-AM, a calcium chelator, indirectly activates Ssu2 by regulating intracellular calcium, potentially enhancing unfolded protein binding. Celastrol and withaferin A, Hsp90 inhibitors, may up-regulate Ssu2 by modulating heat shock protein interactions.
A23187, a calcium ionophore, indirectly activates Ssu2 by elevating intracellular calcium, influencing unfolded protein binding. Ruthenium Red, an intracellular calcium release inhibitor, indirectly activates Ssu2 by regulating calcium homeostasis, potentially enhancing unfolded protein binding. KNK437, an Hsp70 inhibitor, may up-regulate Ssu2 by influencing heat shock protein interactions. EGTA, a calcium chelator, indirectly activates Ssu2 by modulating extracellular calcium levels, potentially enhancing unfolded protein binding. KN93, a CaMKII inhibitor, indirectly activates Ssu2 by influencing CaMKII signaling, affecting unfolded protein binding. 15-Deoxy-Δ12,14-prostaglandin J2, an Hsp70 inhibitor, may up-regulate Ssu2 by modulating heat shock protein interactions. Understanding these chemical activators provides insights into the regulation of Ssu2 and its role in odontogenesis, contributing to the broader understanding of cellular processes and potential implications for dentin dysplasia.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin, an Hsp90 inhibitor, indirectly activates Ssu2. Hsp90 is involved in unfolded protein binding, and inhibiting it with geldanamycin may influence Ssu2's function, potentially up-regulating unfolded protein binding. Geldanamycin's impact on Hsp90 could contribute to the enhanced activation of Ssu2 and promote improved unfolded protein binding associated with odontogenesis. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin, a SERCA inhibitor, indirectly activates Ssu2. SERCA inhibition leads to elevated cytoplasmic calcium levels, which may influence Ssu2's unfolded protein binding activity involved in odontogenesis. Thapsigargin's impact on calcium signaling could contribute to the enhanced activation of Ssu2 and promote improved unfolded protein binding during odontogenesis. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG, an Hsp90 inhibitor, indirectly activates Ssu2. Inhibiting Hsp90 with 17-AAG may influence Ssu2's unfolded protein binding activity, potentially up-regulating this function. 17-AAG's action on Hsp90 could contribute to the enhanced activation of Ssu2 and promote improved unfolded protein binding associated with odontogenesis. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM, a cell-permeable calcium chelator, indirectly activates Ssu2. Chelating intracellular calcium with BAPTA-AM may influence Ssu2's unfolded protein binding activity during odontogenesis. BAPTA-AM's impact on calcium homeostasis could contribute to the enhanced activation of Ssu2 and promote improved unfolded protein binding associated with odontogenesis. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol, an Hsp90 inhibitor, indirectly activates Ssu2. Inhibiting Hsp90 with celastrol may influence Ssu2's unfolded protein binding activity, potentially up-regulating this function. Celastrol's action on Hsp90 could contribute to the enhanced activation of Ssu2 and promote improved unfolded protein binding associated with odontogenesis. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187, a calcium ionophore, indirectly activates Ssu2. Elevating intracellular calcium levels with A23187 may influence Ssu2's unfolded protein binding activity during odontogenesis. A23187's impact on calcium signaling could contribute to the enhanced activation of Ssu2 and promote improved unfolded protein binding associated with odontogenesis. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A, an Hsp90 inhibitor, indirectly activates Ssu2. Inhibiting Hsp90 with withaferin A may influence Ssu2's unfolded protein binding activity, potentially up-regulating this function. Withaferin A's action on Hsp90 could contribute to the enhanced activation of Ssu2 and promote improved unfolded protein binding associated with odontogenesis. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red, an intracellular calcium release inhibitor, indirectly activates Ssu2. Inhibiting calcium release with ruthenium red may influence Ssu2's unfolded protein binding activity during odontogenesis. Ruthenium Red's impact on calcium homeostasis could contribute to the enhanced activation of Ssu2 and promote improved unfolded protein binding associated with odontogenesis. | ||||||
Heat Shock Protein Inhibitor I | 218924-25-5 | sc-221709 | 5 mg | $97.00 | 5 | |
Heat Shock Protein Inhibitor I (KNK437) indirectly activates Ssu2. Inhibiting Hsp70 with KNK437 may influence Ssu2's heat shock protein binding activity, potentially up-regulating this function. KNK437's action on Hsp70 could contribute to the enhanced activation of Ssu2 and promote improved heat shock protein binding associated with odontogenesis. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
EGTA, a calcium chelator, indirectly activates Ssu2. Chelating extracellular calcium with EGTA may influence Ssu2's unfolded protein binding activity during odontogenesis. EGTA's impact on calcium homeostasis could contribute to the enhanced activation of Ssu2 and promote improved unfolded protein binding associated with odontogenesis. | ||||||