Molecular structure of Heat Shock Protein Inhibitor I, CAS Number: 218924-25-5
Heat Shock Protein Inhibitor I (CAS 218924-25-5)
See product citations (5)
Alternate Names:
KNK437; N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam; Hsp70 Induction Inhibitor I
Application:
Heat Shock Protein Inhibitor I is an HSP 70, HSP 72, and HSP 105 inhibitor
CAS Number:
218924-25-5
Purity:
≥95%
Molecular Weight:
245.23
Molecular Formula:
C13H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Heat Shock Protein Inhibitor I is a benzylidene lactam compound that blocks the induction of heat shock proteins. Heat Shock Protein Inhibitor I inhibits HSP 70, HSP 72, and HSP 105. Heat Shock Protein Inhibitor I blocks the development of thermotolerance in a dose-dependent manner. Heat Shock Protein Inhibitor I does not affect the thermosensitivity of nontolerant cells. Heat Shock Protein Inhibitor I does not have an affect on the activities of PKA, PKC, or PTK.
Heat Shock Protein Inhibitor I (CAS 218924-25-5) References
- Trimethylamine oxide suppresses stress-induced alteration of organic anion transport in choroid plexus. | Villalobos, AR. and Renfro, JL. 2007. J Exp Biol. 210: 541-52. PMID: 17234624
- Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3. | Abarzua, F., et al. 2007. Int J Mol Med. 20: 37-43. PMID: 17549386
- HSP70, the earliest-induced gene in the zebrafish retina during optic nerve regeneration: its role in cell survival. | Nagashima, M., et al. 2011. Neurochem Int. 58: 888-95. PMID: 21338645
- KNK437, abrogates hypoxia-induced radioresistance by dual targeting of the AKT and HIF-1α survival pathways. | Oommen, D. and Prise, KM. 2012. Biochem Biophys Res Commun. 421: 538-43. PMID: 22521642
- The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. | Filone, CM., et al. 2014. PLoS Pathog. 10: e1003904. PMID: 24516381
- Heat shock protein 70 induction by valproic acid delays photoreceptor cell death by N-methyl-N-nitrosourea in mice. | Koriyama, Y., et al. 2014. J Neurochem. 130: 707-19. PMID: 24773621
- Multi-faceted proteomic characterization of host protein complement of Rift Valley fever virus virions and identification of specific heat shock proteins, including HSP90, as important viral host factors. | Nuss, JE., et al. 2014. PLoS One. 9: e93483. PMID: 24809507
- β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. | Piedrahita, D., et al. 2015. Front Cell Neurosci. 9: 498. PMID: 26778963
- Pharmacological or Genetic Activation of Hsp70 Protects against Loss of Parkin Function. | Zhang, CW., et al. 2016. Neurodegener Dis. 16: 304-16. PMID: 26886023
- Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway. | Shen, Y., et al. 2017. Oncoimmunology. 6: e1362527. PMID: 29209566
- KNK437 restricts the growth and metastasis of colorectal cancer via targeting DNAJA1/CDC45 axis. | Yang, S., et al. 2020. Oncogene. 39: 249-261. PMID: 31477839
- Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer. | Wu, D., et al. 2021. Free Radic Biol Med. 170: 150-178. PMID: 33450375
- Lysophosphatidylcholine exerts an anti-skin photoaging effect via heat shock protein 70 induction. | Hwang, H., et al. 2021. J Cosmet Dermatol. 20: 4060-4067. PMID: 33714221
Inhibitor of:
βA4-crystallin, Bag-2, Bag-5, COL2A1, COL4A5, D630042P16Rik, HSBP1, HSBP1L1, HSC 70, HSF1, HSF2, HSF3, HSF4, HSFX1, HSP, HSP 105, HSP 27, HSP 70, HSPA12A, HSPA2, HSPA4L, HSPB9, HSPC159, prefoldin 6, Ssa1, and TCP-1 α.Activator of:
D630042P16Rik, HSFY2, HSPBAP1, PhLP, and ZC3H11A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Heat Shock Protein Inhibitor I, 5 mg | sc-221709 | 5 mg | $95.00 |