Cytokeratin 75 Inhibitors
Chemical inhibitors of Cytokeratin 75 can affect the protein by interacting with the cellular components that are crucial for the organization and stability of intermediate filaments. Withaferin A is one such chemical that binds to annexin II, a protein associated with the regulation of cytoskeletal elements, including intermediate filaments. The binding of Withaferin A to annexin II can lead to a disruption of the intermediate filament network, which can inhibit Cytokeratin 75 by preventing its proper assembly and function within the cell. Similarly, Griseofulvin interferes with microtubule function, which is known to have a close functional relationship with intermediate filaments. By disrupting microtubule dynamics, Griseofulvin can indirectly lead to the mislocalization and functional inhibition of Cytokeratin 75, as the cytoskeletal architecture is altered. Colchicine and Nocodazole, which bind to tubulin and inhibit its polymerization, can also disrupt the spatial organization of Cytokeratin 75, consequently inhibiting its function.
Moreover, Paclitaxel, by stabilizing microtubules, could indirectly interfere with the intermediate filament organization, affecting the function of Cytokeratin 75. The microtubule assembly inhibitors Podophyllotoxin and Nocodazole can also result in alterations to the intermediate filament network, leading to functional inhibition of Cytokeratin 75. Actin filament disruptors, such as Cytochalasin D and Swinholide A, can indirectly affect Cytokeratin 75 by disrupting the actin cytoskeleton, which in turn can affect the intermediate filament network stability and organization. Similarly, Latrunculin B prevents actin polymerization, and Jasplakinolide stabilizes actin filaments, both of which can lead to a secondary disorganization of intermediate filaments and therefore inhibit the function of Cytokeratin 75. Lastly, Chelidonine and Sanguinarine, known to disrupt cytoskeletal dynamics, can alter the structural integrity of intermediate filaments, leading to the functional inhibition of Cytokeratin 75 by destabilizing the network it relies on for proper cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Withaferin A binds to annexin II, which is known to be involved in the organization of intermediate filaments, including cytokeratins. Binding to annexin II may lead to a reorganization or destabilization of the intermediate filament network, thus functionally inhibiting Cytokeratin 75. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule function and can indirectly affect intermediate filament dynamics. This disruption can lead to a mislocalization and functional inhibition of intermediate filament proteins such as Cytokeratin 75 by altering the cellular architecture. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, inhibiting microtubule polymerization. As microtubules are important for the spatial organization of cytokeratins, colchicine's action can result in the indirect functional inhibition of Cytokeratin 75 by disrupting its distribution within cells. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and can indirectly interfere with the dynamics of intermediate filaments. This stabilization might inhibit the proper organization and functioning of Cytokeratin 75 within the intermediate filament network. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule networks by inhibiting their polymerization, which could indirectly lead to the disorganization of intermediate filaments and the subsequent functional inhibition of Cytokeratin 75 due to alterations in cytoskeletal dynamics. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin inhibits microtubule assembly, which can indirectly lead to cytokeratin disorganization. This inhibition might prevent the proper functioning of Cytokeratin 75 by altering its association within intermediate filaments. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D disrupts actin filaments, another component of the cytoskeleton, which may indirectly affect the integrity and function of the intermediate filament network where Cytokeratin 75 is situated, leading to its functional inhibition. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A severs actin filaments and could indirectly affect intermediate filaments. This actin disruption may lead to a cellular reorganization that functionally inhibits Cytokeratin 75 by impacting the structural support that intermediate filaments provide. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin B binds to actin monomers and prevents their polymerization, potentially leading to a secondary disorganization of intermediate filaments, thus functionally inhibiting Cytokeratin 75 by affecting the overall cytoskeletal network. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and could indirectly disrupt intermediate filament dynamics. This could lead to a functional inhibition of Cytokeratin 75 by interfering with the cytoskeletal interactions that are necessary for its proper function. | ||||||