Cytokeratin 7 Inhibitors
Cytokeratin 7 (CK7) is a type of keratin, which is a protein that is a critical component of the cytoskeleton in epithelial cells. It is one of a large family of keratins, which are divided into two categories: type I (acidic) keratins and type II (basic to neutral) keratins. CK7 belongs to the type II category and is specifically expressed in the epithelial cells of various tissues, including the lungs, breast, and ovary. It is involved in providing structural support to the cells, helping to maintain their shape and integrity. Cytokeratin 7 inhibitors, therefore, are chemical compounds that interact with CK7 and disrupt its normal function.
These inhibitors can bind to CK7 in different ways, altering its structure, hindering its ability to form filaments, or interfering with its interactions with other proteins. This disruption can affect the stability and resilience of the epithelial cells' cytoskeleton, impacting their shape and possibly leading to cellular damage. The exact mechanism of action of these inhibitors depends on their chemical structure and the way they interact with CK7. The development and study of CK7 inhibitors require a deep understanding of protein chemistry, as well as knowledge of the cellular processes that involve CK7. Despite the complexity of their interactions, studying CK7 inhibitors is crucial for unraveling the intricate web of cellular functions and the role of cytokeratins in maintaining cellular integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
This compound is a DNA methyltransferase inhibitor, reducing methylation levels of genomic DNA. Demethylation can reactivate silenced genes, potentially influencing the expression of cytokeratin 7 in epithelial cells. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that affects chromatin structure and gene expression. By altering the acetylation status of histones, it could modulate the expression of genes like cytokeratin 7. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, another histone deacetylase inhibitor, modifies chromatin accessibility and can lead to changes in gene expression. It may influence the transcriptional activity of genes, potentially including cytokeratin 7. | ||||||
3-Deazaneplanocin, HCl salt | 120964-45-6 | sc-351856 sc-351856A sc-351856B | 1 mg 5 mg 10 mg | $256.00 $612.00 $936.00 | 2 | |
This compound inhibits S-adenosylhomocysteine hydrolase, leading to alterations in epigenetic marks on DNA and histones. These changes could affect the expression of a variety of genes, possibly including cytokeratin 7. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX-01294 is a G9a histone methyltransferase inhibitor. By altering histone methylation status, it can influence gene expression. This might modulate the levels of proteins like cytokeratin 7 in certain cell types. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to have a variety of biological effects, including modulation of gene expression. It may influence the transcriptional activity of several genes, potentially impacting the expression of cytokeratin 7. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol affects numerous signaling pathways and has been reported to modulate gene expression. It could potentially influence the expression of proteins like cytokeratin 7 through its actions on cellular signaling and transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea, this compound has been shown to influence gene expression and cell proliferation. It might modulate the levels of various proteins, including cytokeratin 7, through its effects on cellular pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, a compound found in cruciferous vegetables, has been shown to affect gene expression and cell proliferation. It may influence the expression of proteins like cytokeratin 7 through its biological activities. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram has shown potential in influencing gene expression. Its effects on cellular pathways could potentially impact the expression levels of proteins like cytokeratin 7. | ||||||