CYP7A1 Activators
The cytochrome P450 family plays a vital role in various physiological processes, including the metabolism of drugs, toxins, and endogenous substrates in the human body. Among this family, the enzyme CYP7A1, or cytochrome P450 family 7 subfamily A member 1, stands out due to its specific function in cholesterol metabolism. CYP7A1 is primarily responsible for the conversion of cholesterol to 7α-hydroxycholesterol, which is the rate-limiting step in the synthesis of bile acids in the liver. These bile acids, in turn, play a crucial role in the digestion and absorption of dietary fats, and their synthesis helps in regulating overall cholesterol levels in the body.
The activity of CYP7A1 is subject to various regulatory mechanisms to ensure homeostasis in cholesterol and bile acid levels. It is here that CYP7A1 activators come into play. CYP7A1 activators are chemical compounds that enhance the activity of the CYP7A1 enzyme. By doing so, they can potentially influence the rate at which cholesterol is converted to bile acids. While various factors, such as hormones, nutrients, and other endogenous compounds, can regulate CYP7A1 activity, specific activators can be designed or identified to directly stimulate the enzyme's activity. An increased understanding of these activators can pave the way for a deeper comprehension of cholesterol metabolism and its intricate regulation in the body.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholic acid | 81-25-4 | sc-255020 sc-255020A sc-255020B sc-255020C sc-255020D | 25 g 100 g 500 g 1 kg 5 kg | $48.00 $121.00 $567.00 $998.00 $4480.00 | 11 | |
Cholic acid is a primary bile acid that can feedback regulate its own synthesis by affecting CYP7A1 expression. Increased levels may elevate CYP7A1 expression as a compensatory response. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin is an antibiotic that can induce CYP7A1 expression, potentially through activation of certain nuclear receptors. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate, a hypolipidemic agent, can enhance CYP7A1 expression, possibly as a mechanism to increase bile acid synthesis and decrease cholesterol. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone, a corticosteroid, can induce CYP7A1, potentially reflecting its role in modulating metabolic responses and lipid metabolism. | ||||||
5-Pregnen-3β-ol-20-one-16α-carbonitrile | 1434-54-4 | sc-227010 | 50 mg | $68.00 | 3 | |
PCN has been demonstrated to induce CYP7A1 expression, possibly by activating nuclear receptors involved in lipid metabolism. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may induce CYP7A1 expression by binding to retinoid X receptors (RXRs), which play roles in cholesterol and lipid metabolism. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $40.00 $75.00 $150.00 | ||
Thyroid hormone can increase CYP7A1 expression, reflecting its influence on basal metabolic rate and lipid metabolism. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $81.00 | 5 | |
Leflunomide may enhance CYP7A1 expression, although the exact mechanism remains unclear; it could relate to its broader effects on metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, an activator of adenylate cyclase, might elevate CYP7A1 expression by increasing intracellular cAMP levels, which in turn can impact gene expression. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $319.00 | ||
Silymarin, a compound from milk thistle, may induce CYP7A1, potentially due to its effects on liver health and lipid metabolism. | ||||||