Molecular structure of 5-Pregnen-3β-ol-20-one-16α-carbonitrile, CAS Number: 1434-54-4
5-Pregnen-3β-ol-20-one-16α-carbonitrile (CAS 1434-54-4)
See product citations (3)
Alternate Names:
Pregnenolone carbonitrile; Pregnenolone-16α-carbonitrile
Application:
5-Pregnen-3β-ol-20-one-16α-carbonitrile is an activator of Cyp2c55
CAS Number:
1434-54-4
Molecular Weight:
341.49
Molecular Formula:
C22H31NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Recent studies have shown that this product activates the Cyp2c55 in mouse kidney and liver.
5-Pregnen-3β-ol-20-one-16α-carbonitrile (CAS 1434-54-4) References
- Liquid chromatography-electrospray ionization mass spectrometric analysis of corticosterone in rat plasma using selected ion monitoring. | Marwah, A., et al. 2001. J Chromatogr B Biomed Sci Appl. 757: 333-42. PMID: 11417879
- A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene. | Zhang, W., et al. 2003. Drug Metab Dispos. 31: 1054-64. PMID: 12867495
- Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. | Squires, EJ., et al. 2004. J Biol Chem. 279: 49307-14. PMID: 15347657
- The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice. | Teng, S. and Piquette-Miller, M. 2005. J Pharmacol Exp Ther. 312: 841-8. PMID: 15456840
- Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor. | Jackson, JP., et al. 2006. Drug Metab Dispos. 34: 2003-10. PMID: 16936065
- PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice. | de Haan, W., et al. 2009. Biochim Biophys Acta. 1791: 191-7. PMID: 19150509
- The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver. | Konno, Y., et al. 2010. Drug Metab Dispos. 38: 1177-82. PMID: 20371638
- Activation of pregnane X receptor inhibits experimental dermal fibrosis. | Beyer, C., et al. 2013. Ann Rheum Dis. 72: 621-5. PMID: 23291432
Activator of:
CYP17A1, CYP2F2, Cyp3a18, CYP3A4, CYP3A5, CYP3A7, CYP7A1, MB67_CAR1/2, PXR, and UGT3A1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Pregnen-3β-ol-20-one-16α-carbonitrile, 50 mg | sc-227010 | 50 mg | $69.00 |