Cyp4f16 Activators
Cyp4f16, belonging to the cytochrome P450 family, is a pivotal player in diverse physiological processes, as indicated by its expression in multiple structures, including the cardiovascular system, central nervous system, endocrine gland, genitourinary system, and intestine. The gene encoding Cyp4f16, known as cytochrome P450, family 4, subfamily f, polypeptide 16, demonstrates a wide tissue distribution, underscoring its importance in maintaining cellular homeostasis across various systems within the organism. The function of Cyp4f16 is intricately linked to its role as a cytochrome P450 enzyme, contributing to the metabolism of endogenous and exogenous compounds. While the exact substrates of Cyp4f16 are not explicitly outlined, the broad tissue expression pattern suggests a role in processing a diverse array of molecules, including lipids and xenobiotics. As a member of the cytochrome P450 family, Cyp4f16 likely participates in the oxidative metabolism of these substrates, facilitating their transformation and elimination from the body. The involvement of Cyp4f16 in such fundamental processes across different anatomical structures underscores its significance in maintaining cellular function and overall organismal health.
The activation of Cyp4f16 involves a sophisticated network of regulatory mechanisms, with various signaling pathways playing key roles in modulating its expression and activity. These pathways include but are not limited to NF-κB, NRF2/ARE, AhR, STAT3, PI3K/Akt, PPARγ, JAK/STAT, KEAP1/NRF2, and PPARα. Indirect activators influence Cyp4f16 expression by targeting these pathways, creating an environment conducive to heightened cytochrome P450 activity. The intricate interplay between these signaling cascades reflects the dynamic nature of Cyp4f16 regulation, where the fine-tuning of its activation contributes to maintaining cellular and physiological balance. Understanding the detailed biochemical and cellular mechanisms governing Cyp4f16 activation provides valuable insights into the regulatory network that orchestrates its function across diverse tissues, advancing our comprehension of the intricate molecular processes underlying cytochrome P450-mediated metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol, activates Cyp4f16 by modulating the SIRT1/AMPK pathway. It enhances cellular energy sensing, indirectly upregulating Cyp4f16 expression. Resveratrol's influence on SIRT1 promotes downstream effects, leading to heightened Cyp4f16 activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, indirectly stimulates Cyp4f16 through inhibition of NF-κB signaling. By blocking NF-κB, quercetin disrupts the suppressive effects on Cyp4f16 expression, fostering an environment that favors the activation of this cytochrome P450 enzyme. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $47.00 $133.00 | 21 | |
Thymoquinone activates Cyp4f16 by targeting the NRF2/ARE pathway. Its interaction with NRF2 enhances the antioxidant response, indirectly influencing Cyp4f16 expression. Thymoquinone's impact on cellular redox balance creates conditions conducive to the activation of Cyp4f16. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $37.00 $65.00 $89.00 $421.00 $681.00 $66.00 | 8 | |
3,3'-Diindolylmethane activates Cyp4f16 via modulation of the AhR pathway. By binding to AhR, it induces transcriptional changes that positively regulate Cyp4f16 expression. The interaction with AhR serves as a molecular trigger leading to the activation of Cyp4f16. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenol, indirectly stimulates Cyp4f16 through inhibition of the STAT3 pathway. By suppressing STAT3 activation, curcumin alleviates its inhibitory effect on Cyp4f16, promoting the cytochrome P450 enzyme's expression and subsequent activation. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
α-Lipoic Acid activates Cyp4f16 by influencing the Nrf2/HO-1 pathway. It enhances Nrf2-mediated antioxidant responses, indirectly fostering an environment that supports increased Cyp4f16 expression. Alpha-Lipoic Acid's action serves as an upstream trigger for Cyp4f16 activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone, indirectly stimulates Cyp4f16 through modulation of the PI3K/Akt pathway. By activating Akt, genistein creates a cellular milieu that supports increased Cyp4f16 expression, acting as an indirect activator for this cytochrome P450 enzyme. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $86.00 $302.00 | 8 | |
Oleanolic Acid activates Cyp4f16 through the PPARγ pathway. By interacting with PPARγ, it induces transcriptional changes that positively regulate Cyp4f16 expression. Oleanolic Acid's impact on PPARγ serves as a molecular trigger leading to the activation of Cyp4f16. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol, a flavonoid, indirectly stimulates Cyp4f16 through inhibition of the JAK/STAT pathway. By suppressing JAK/STAT activation, kaempferol alleviates its inhibitory effect on Cyp4f16, promoting the cytochrome P450 enzyme's expression and subsequent activation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane activates Cyp4f16 via modulation of the KEAP1/NRF2 pathway. Its interaction with KEAP1 releases NRF2, enhancing antioxidant responses and indirectly supporting increased Cyp4f16 expression. Sulforaphane's influence creates conditions favorable for Cyp4f16 activation. | ||||||