Cyp3a59 Inhibitors
Cyp3a59, a member of the cytochrome P450 superfamily, plays a pivotal role in cellular functions such as caffeine oxidase activity, iron ion binding activity, and monooxygenase activity. Positioned within the cytoplasm, it is intricately involved in oxidative demethylation and the steroid metabolic process. Implications in diseases such as B-lymphoblastic leukemia/lymphoma, acute lymphoblastic leukemia, chronic myeloid leukemia, essential hypertension, and familial Mediterranean fever underscore its significance as a potential research target.
Exploration of inhibitors for Cyp3a59 reveals a repertoire of chemicals that either directly or indirectly modulate its functions. Direct inhibitors like Ketoconazole, Fluconazole, Clotrimazole, Itraconazole, Voriconazole, Miconazole, Terbinafine act by specifically suppressing monooxygenase activity within the cytoplasm, impacting caffeine oxidase and iron ion binding activities. Indirect inhibitors such as Fluoxetine, Cimetidine, Ranitidine, Gemfibrozil, and Fenofibrate influence the oxidative demethylation process and the steroid metabolic process, indirectly impacting monooxygenase activity and inhibiting the target protein. Understanding the intricate regulatory network of Cyp3a59 and its interactions with these inhibitors provides valuable insights into its physiological roles and potential implications in disease states. Further research is essential to elucidate the detailed mechanisms underlying these interactions and to explore the relevance of targeting Cyp3a59 in various pathological conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Antifungal agent in research acting as a direct inhibitor of Cyp3a59. By specifically suppressing monooxygenase activity, it directly hinders the target protein within the cytoplasm, impacting caffeine oxidase and iron ion binding activities. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $53.00 $84.00 | 14 | |
Azole antifungal compound known to directly inhibit Cyp3a59. By specifically suppressing monooxygenase activity, it directly hinders the target protein within the cytoplasm, impacting caffeine oxidase and iron ion binding activities. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $41.00 $56.00 | 6 | |
Imidazole antifungal compound acting as a direct inhibitor of Cyp3a59. By specifically suppressing monooxygenase activity, it directly hinders the target protein within the cytoplasm, impacting caffeine oxidase and iron ion binding activities. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $76.00 $139.00 | 23 | |
Triazole antifungal agent acting as a direct inhibitor of Cyp3a59. By specifically suppressing monooxygenase activity, it directly hinders the target protein within the cytoplasm, impacting caffeine oxidase and iron ion binding activities. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
Imidazole antifungal compound acting as a direct inhibitor of Cyp3a59. By specifically suppressing monooxygenase activity, it directly hinders the target protein within the cytoplasm, impacting caffeine oxidase and iron ion binding activities. | ||||||
Terbinafine | 91161-71-6 | sc-338609 | 100 mg | $560.00 | 1 | |
Antifungal agent in research known to directly inhibit Cyp3a59. By suppressing monooxygenase activity, it directly hinders the target protein within the cytoplasm, impacting caffeine oxidase and iron ion binding activities. | ||||||
Fluoxetine | 54910-89-3 | sc-279166 | 500 mg | $312.00 | 9 | |
Selective serotonin reuptake inhibitor (SSRI) acting as an indirect inhibitor of Cyp3a59. By influencing the oxidative demethylation process, it indirectly impacts monooxygenase activity and inhibits the target protein within the cytoplasm, affecting caffeine oxidase and iron ion binding activities. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Histamine H2 receptor antagonist acting as an indirect inhibitor of Cyp3a59. By influencing the oxidative demethylation process, it indirectly impacts monooxygenase activity and inhibits the target protein within the cytoplasm, affecting caffeine oxidase and iron ion binding activities. | ||||||
Ranitidine | 66357-35-5 | sc-203679 | 1 g | $189.00 | ||
Histamine H2 receptor antagonist known to indirectly inhibit Cyp3a59. By influencing the oxidative demethylation process, it indirectly impacts monooxygenase activity and inhibits the target protein within the cytoplasm, affecting caffeine oxidase and iron ion binding activities. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $65.00 $262.00 | 2 | |
Fibrate agent in research acting as an indirect inhibitor of Cyp3a59. By influencing the steroid metabolic process, it indirectly impacts monooxygenase activity and inhibits the target protein within the cytoplasm, affecting caffeine oxidase and iron ion binding activities. | ||||||