Cyp3a13 Inhibitors
CYP3A13 inhibitors belong to a class of chemical compounds that are specifically designed to modulate the activity of the cytochrome P450 3A13 enzyme. Cytochrome P450 (CYP) enzymes play a critical role in the metabolism of a wide range of endogenous and exogenous compounds, including drugs, toxins, and various endogenous substrates. CYP3A13 is a subtype of the CYP3A family of enzymes, which are primarily expressed in the liver and are known for their involvement in the oxidative metabolism of numerous drugs and xenobiotics. Inhibition of CYP3A13 activity can have significant implications for the pharmacokinetics of certain drugs, leading to altered drug levels in the body.
CYP3A13 inhibitors are compounds that interfere with the normal enzymatic activity of CYP3A13, thereby slowing down the metabolism of substrates that are normally processed by this enzyme. This inhibition can result in increased concentrations of specific drugs or other xenobiotics in the bloodstream, leading to altered pharmacological effects or increased risk of adverse reactions. Understanding the mechanisms and properties of CYP3A13 inhibitors is of paramount importance in the field of drug development and toxicology, as it helps researchers and scientists predict and mitigate drug-drug interactions and adverse effects. Additionally, these inhibitors can serve as valuable tools in experimental studies aimed at elucidating the role of CYP3A13 in the metabolism of various compounds, contributing to a deeper understanding of metabolism and xenobiotic processing in the body.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole is known to inhibit cytochrome P450 enzymes, potentially leading to decreased Cyp3a13 expression through competitive binding. | ||||||
Ritonavir | 155213-67-5 | sc-208310 | 10 mg | $124.00 | 7 | |
Ritonavir can inhibit various cytochrome P450 enzymes, which may include Cyp3a13, thus potentially reducing its expression. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
As a calcium channel blocker, Diltiazem has been shown to inhibit cytochrome P450 enzymes, possibly affecting Cyp3a13 expression. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine, a histamine H2 receptor antagonist, can inhibit cytochrome P450 activity, which may influence Cyp3a13 levels. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Erythromycin is a compound that inhibits cytochrome P450 enzymes, potentially reducing Cyp3a13 expression by this mechanism. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Itraconazole can inhibit several cytochrome P450 enzymes, which may include Cyp3a13, thereby potentially decreasing its expression. | ||||||
Clarithromycin | 81103-11-9 | sc-205634 sc-205634A | 100 mg 250 mg | $77.00 $122.00 | 1 | |
Clarithromycin inhibits cytochrome P450 enzymes and could influence the expression of Cyp3a13 by a similar mechanism. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $66.00 $160.00 | 2 | |
Miconazole is an antifungal agent that inhibits cytochrome P450 enzymes, which could lead to decreased Cyp3a13 expression. | ||||||
Amiodarone | 1951-25-3 | sc-480089 | 5 g | $318.00 | ||
Amiodarone affects cytochrome P450 enzymes, which might include inhibitory effects on Cyp3a13 expression. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $54.00 $84.00 | 14 | |
Fluconazole inhibits several cytochrome P450 enzymes, potentially affecting Cyp3a13 expression levels. | ||||||