CTP Inhibitors
CTP inhibitors, short for Cytidine Triphosphate inhibitors, belong to a distinctive chemical class that plays a pivotal role in regulating cellular processes involving nucleotide metabolism. These inhibitors target the enzyme CTP synthetase, a key player in de novo pyrimidine biosynthesis. CTP synthetase catalyzes the conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP), a crucial step in the synthesis of RNA, DNA, and other essential cellular components. By impeding the activity of CTP synthetase, CTP inhibitors disrupt the balance of nucleotide pools, exerting a profound impact on cellular physiology.
CTP inhibitors encompass a diverse array of chemical compounds, each designed to interact with specific binding sites on CTP synthetase. These compounds may operate through competitive or allosteric mechanisms, influencing the enzyme's catalytic activity and, consequently, modulating the availability of CTP within the cell. This nuanced regulation of nucleotide biosynthesis holds significance not only for fundamental cellular processes but also for potential applications in various fields, such as molecular biology and biochemistry. The study of CTP inhibitors contributes valuable insights into the intricate web of cellular signaling pathways, providing researchers with tools to dissect and manipulate these processes for a deeper understanding of cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $102.00 $408.00 $642.00 $1275.00 | 10 | |
Acivicin is an analog of glutamine and inhibits CTP synthase by competing with glutamine, one of the substrates necessary for the enzyme's activity. | ||||||
6-Diazo-5-oxo-L-norleucine | 157-03-9 | sc-227078 sc-227078A sc-227078B sc-227078C | 5 mg 25 mg 100 mg 250 mg | $82.00 $285.00 $908.00 $2152.00 | ||
DON is a glutamine antagonist that inhibits several glutamine-utilizing enzymes, including CTP synthase. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
This purine analog is primarily known as a cyclin-dependent kinase inhibitor but also inhibits CTP synthase. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
Allopurinol is a purine analog that can indirectly affect CTP levels by influencing the overall nucleotide pool balance. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
An antiviral nucleoside analog that can lead to imbalances in the nucleotide pools and therefore indirectly inhibit CTP synthesis. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Inhibits inosine monophosphate dehydrogenase, leading to decreased levels of guanosine nucleotides and a compensatory increase in CTP synthesis inhibition. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Initially identified as a kinase inhibitor, flavopiridol also impacts nucleotide synthesis enzymes including CTP synthase. | ||||||
Clofarabine | 123318-82-1 | sc-278864 sc-278864A | 10 mg 50 mg | $185.00 $781.00 | ||
A purine nucleoside analog that, through its action on the cellular nucleotide pool, indirectly affects CTP synthase function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Incorporated into RNA and DNA and affects the balance of nucleotides in the cell, thereby indirectly influencing CTP synthase. | ||||||
Tetrahydrouridine | 18771-50-1 | sc-204339 | 10 mg | $408.00 | 1 | |
Inhibitor of cytidine deaminase, which can lead to increased levels of cytidine and thereby feedback inhibition of CTP synthase. | ||||||