Molecular structure of Tetrahydrouridine, CAS Number: 18771-50-1
Tetrahydrouridine (CAS 18771-50-1)
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Alternate Names:
3,4,5,6-Tetrahydrouridine; THU
Application:
Tetrahydrouridine is a CDD inhibitor which may prevent growth of CDA-expressing tumors
CAS Number:
18771-50-1
Purity:
≥80%
Molecular Weight:
248.23
Molecular Formula:
C9H16N2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tetrahydrouridine is a chemical compound known for its role as a modulator of biochemical processes. It is characterized by its ability to inhibit cytidine deaminase, an enzyme that is involved in the metabolism of certain nucleosides within cells. By hindering this enzyme, tetrahydrouridine can affect the breakdown and utilization of these nucleosides. In various research applications, tetrahydrouridine is used to study enzyme kinetics and to investigate the metabolic pathways of nucleosides. Its ability to modulate enzyme activity makes it useful for scientists exploring the complex web of biochemical reactions that occur within living organisms.
Tetrahydrouridine (CAS 18771-50-1) References
- Stability of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in combination. | Guo, D., et al. 2010. AAPS PharmSciTech. 11: 247-52. PMID: 20151336
- Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine. | Lavelle, D., et al. 2012. Blood. 119: 1240-7. PMID: 22160381
- Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. | Funamizu, N., et al. 2012. PLoS One. 7: e37424. PMID: 22616006
- Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice. | Terse, P., et al. 2014. Int J Toxicol. 33: 75-85. PMID: 24639139
- Validation of a hydrophilic interaction ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of gemcitabine in human plasma with tetrahydrouridine. | Mano, Y., et al. 2015. Biomed Chromatogr. 29: 1343-9. PMID: 25641274
- Tetrahydrouridine, cytidine analogues, and hemoglobin F. | DeSimone, J., et al. 1985. Am J Hematol. 18: 283-8. PMID: 2579548
- Preclinical studies of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in pediatric brain tumors. | Morfouace, M., et al. 2016. J Neurooncol. 126: 225-34. PMID: 26518542
- Selective radiosensitization and cytotoxicity of human melanoma cells using halogenated deoxycytidines and tetrahydrouridine. | Lawrence, TS. and Davis, MA. 1989. Int J Radiat Oncol Biol Phys. 16: 1243-6. PMID: 2715074
- A pilot clinical trial of the cytidine deaminase inhibitor tetrahydrouridine combined with decitabine to target DNMT1 in advanced, chemorefractory pancreatic cancer. | Sohal, D., et al. 2020. Am J Cancer Res. 10: 3047-3060. PMID: 33042633
- In vitro drug-drug interactions of decitabine and tetrahydrouridine involving drug transporters and drug metabolising enzymes. | Säll, C. and Fogt Hjorth, C. 2022. Xenobiotica. 52: 1-15. PMID: 34913834
- Effects of tetrahydrouridine on the uptake and metabolism of 1-beta-D-arabinofuranosylcytosine in human normal and leukemic cells. | Ho, DH., et al. 1980. Cancer Res. 40: 2444-6. PMID: 6248205
- Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies. | Mekras, JA., et al. 1984. Cancer Res. 44: 2551-60. PMID: 6539164
Inhibitor of:
CDD, CTP, Mex67p, SAMHD1, TET1, and UPase.Activator of:
APOBEC3H, CDD, and FucT-l.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tetrahydrouridine, 10 mg | sc-204339 | 10 mg | $416.00 |