CTAP-III Inhibitors
CTAP-III inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the Connective Tissue Activating Peptide-III (CTAP-III), a protein derived from platelet basic protein (PBP) and a member of the CXC chemokine family. CTAP-III plays a significant role in various cellular processes, including the modulation of inflammation, immune responses, and the regulation of cell proliferation and migration. It is a multifunctional protein that can act as a precursor to other biologically active peptides, such as NAP-2, through proteolytic processing. CTAP-III's involvement in these processes makes it an important factor in the regulation of cellular environments, particularly in relation to its influence on chemotaxis and the activation of neutrophils and other immune cells.
Inhibitors targeting CTAP-III are typically designed to interfere with the protein's ability to bind to its receptors or to prevent its processing into active peptides like NAP-2. These inhibitors can be small molecules or peptides themselves, engineered to specifically disrupt the interaction of CTAP-III with its target molecules. By inhibiting CTAP-III, these compounds allow researchers to dissect the role of this protein in cellular signaling pathways and its broader impact on cellular function. The structural design of CTAP-III inhibitors often involves mimicking the binding motifs of the natural ligands or blocking critical sites on the protein that are essential for its activity. The study and development of CTAP-III inhibitors provide valuable insights into the mechanisms by which CTAP-III influences cellular behavior and how modulation of this protein can affect various biochemical pathways. This class of inhibitors continues to be refined to enhance their specificity and efficacy, contributing to a deeper understanding of CTAP-III's role in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may decrease CTAP-III expression by blocking the activation of NF-kB, which is a key transcription factor in the inflammatory signaling cascade that could control CTAP-III gene transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol might downregulate CTAP-III expression through its antioxidative action that can disrupt the signaling pathways leading to pro-inflammatory cytokine production, indirectly leading to reduced CTAP-III levels. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin may reduce CTAP-III transcription by inhibiting the activity of the MAPK pathway, which plays a crucial role in cellular responses to stress and inflammation, potentially decreasing the synthesis of related chemokines. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate could decrease the expression of CTAP-III by hindering the DNA-binding activity of transcription factors like AP-1, which may be responsible for the transcriptional activation of genes during the inflammatory response. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane might inhibit the expression of CTAP-III by attenuating the signaling through NF-kB pathway, leading to a decrease in the transcription of genes involved in inflammation and immune response. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein has the potential to downregulate CTAP-III expression by hindering tyrosine kinase activity, which is integral to the signaling pathways that govern the expression of genes during inflammatory processes. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin may lead to a decrease in CTAP-III levels by inhibiting protein kinase C, an enzyme that plays a significant role in controlling the signaling mechanisms that dictate the transcription of inflammatory genes. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol could reduce CTAP-III expression by altering the metabolism and activity of estrogen, which has been shown to have a complex role in modulating inflammatory responses and could thereby affect CTAP-III levels. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide may inhibit CTAP-III expression by obstructing NF-kB translocation to the nucleus, which is essential for the initiation of transcription for many inflammatory mediators, including chemokines like CTAP-III. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol could downregulate CTAP-III by inhibiting the phosphorylation of key enzymes and transcription factors within the inflammatory signaling pathways, leading to a decrease in gene expression related to the inflammatory response. | ||||||