CT45-5 Activators
CT45-5 activators encompass a spectrum of chemical compounds that indirectly enhance the functional activity of CT45-5 through diverse cellular signaling mechanisms. These compounds initiate a cascade of intracellular events that may culminate in the upregulation of CT45-5 expression in specific cancer cells. Some activators achieve this by increasing intracellular cyclic AMP (cAMP) concentrations, leading to the activation of protein kinase A (PKA). PKA, in turn, phosphorylates transcription factors, potentially enhancing the expression of genes associated with cancer/testis antigens, including CT45-5. Similarly, thyroid hormones engage with nuclear receptors to modulate gene expression, potentially increasing the transcription of CT45-5 by remodeling chromatin accessibility. Analog compounds that mimic cAMP are also capable of penetrating cellular membranes and initiating PKA signaling, thereby modulating gene expression patterns that could lead to an elevation of CT45-5 levels in certain neoplastic contexts.
Other activators operate by triggering protein kinase C (PKC), which influences gene expression and cellular differentiation that may affect CT45-5 expression. Increases in intracellular calcium levels can activate calcium-dependent signaling pathways, potentially leading to the modulation of gene expression profiles, including CT45-5 upregulation. Agents that modify the epigenetic landscape, such as inhibitors of DNA methyltransferases and histone deacetylases (HDACs), can induce a more transcriptionally permissive chromatin state, which may enhance CT45-5 gene expression. Furthermore, natural compounds known to modulate various signaling pathways, such as polyphenols and isoflavones, can induce the expression of CT45-5 by interacting with specific molecular targets and altering gene expression dynamics within cancer cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Elevates intracellular cAMP levels, which can activate PKA. PKA phosphorylation can lead to changes in the activity of transcription factors that may enhance the expression of CT45-5 by influencing genes associated with cancer/testis antigens. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $40.00 $75.00 $150.00 | ||
Can modulate gene expression through thyroid hormone receptors which could upregulate genes encoding cancer/testis antigens including CT45-5 by altering chromatin structure and transcriptional activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that can diffuse into cells and mimic the action of endogenous cAMP, potentially activating PKA and modulating gene expression in a manner that could increase CT45-5 levels in specific cancer cells. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which can influence gene expression and cellular differentiation pathways that may affect the expression of CT45-5 in cancer cells. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Increases intracellular calcium concentration, which can activate calcium-dependent signaling pathways potentially leading to the modulation of gene expression that could include the upregulation of CT45-5 in certain cancer cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Activates retinoic acid receptors, which can regulate gene expression including the potential upregulation of cancer/testis antigen genes such as CT45-5 in certain contexts, such as differentiation or cancer cell lines. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can induce hypomethylation of DNA and potentially increase the expression of genes normally silenced by methylation, including possibly CT45-5 in tumor cells. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An inhibitor of histone deacetylases (HDACs) which can lead to a more open chromatin structure, potentially enhancing the expression of genes including CT45-5 by influencing histone acetylation patterns. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
An HDAC inhibitor which can alter gene expression by affecting chromatin structure, potentially increasing transcription of CT45-5 in certain tumor cells by modifying histone acetylation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol found in green tea that has been shown to modulate various signaling pathways and gene expression patterns, which could theoretically include the upregulation of CT45-5 in some cancer cells. | ||||||