CRSP70 Activators
CRSP70 activators encompass a diverse group of chemical compounds that, through various biochemical and cellular pathways, exert influence on the transcription mediator complex component, CRSP70. These activators do not directly bind or interact with CRSP70; instead, they modulate the cellular environment or signaling pathways that indirectly enhance the function or activity of CRSP70.
The primary mechanism by which these activators function is through the modulation of signaling pathways and transcriptional regulation processes. For instance, compounds like Forskolin and Phorbol 12-myristate 13-acetate (PMA) act on key cellular signaling molecules such as adenylate cyclase and protein kinase C, respectively. These activations lead to a cascade of events that culminate in the modulation of transcription factors or coactivators that are part of the transcriptional machinery involving CRSP70. Forskolin, by increasing cAMP levels, activates PKA, which then influences transcription factors in a way that can enhance CRSP70's activity. Similarly, PMA activates PKC, leading to phosphorylation events that can impact transcription factors associated with CRSP70.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. This leads to activation of PKA, which can modulate transcription factors interacting with CRSP70, enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which can phosphorylate transcription factors or coactivators associated with CRSP70, influencing its transcriptional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium concentration, which can activate calcium-dependent signaling pathways impacting transcription factors working with CRSP70. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Inhibits DNA methyltransferases, leading to hypomethylation and potential upregulation of genes that modulate CRSP70 activity or its associated pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Inhibits histone deacetylases, altering chromatin structure and potentially affecting gene expression related to CRSP70's function or regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Histone deacetylase inhibitor, altering chromatin accessibility and potentially influencing genes in CRSP70-related pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Modulates gene expression through retinoic acid receptors, which can interact with transcription complexes involving CRSP70. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3, influencing Wnt signaling and potentially affecting transcription factors or coactivators that interact with CRSP70. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Modulates multiple signaling pathways including NF-kB, which can have downstream effects on transcription regulation involving CRSP70. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Influences multiple signaling pathways, including those involved in inflammation and oxidative stress, potentially impacting transcription factors associated with CRSP70. | ||||||