CRM1 Activators
Common CRM1 Activators include, but are not limited to Actinomycin D CAS 50-76-0, Camptothecin CAS 7689-03-4, Hydroxyurea CAS 127-07-1, Doxorubicin CAS 23214-92-8 and Fluorouracil CAS 51-21-8.
CRM1, also known as Exportin 1 (XPO1), is a protein that plays a vital role in the nucleocytoplasmic transport of proteins and RNA. It is a member of the karyopherin family and specifically functions as a receptor for the nuclear export signals (NES) found on many proteins. CRM1 recognizes these NES motifs and, with the assistance of RanGTP, facilitates the transport of cargo proteins from the nucleus to the cytoplasm, a process essential for maintaining proper cellular function. The proper shuttling of molecules between the nucleus and cytoplasm is crucial for regulating protein localization, modulating gene expression, and maintaining cellular homeostasis. CRM1's role in this transport process underscores its importance in a variety of cellular processes.
CRM1 Activators represents a category of molecules that enhance or stimulate the activity or expression of the CRM1 protein. By promoting the function of CRM1, these activators can amplify the nucleocytoplasmic transport of specific cargo proteins, effectively reshaping the cellular landscape of protein distribution between the nucleus and cytoplasm. Mechanistically, CRM1 activators may act by enhancing the protein's affinity for NES motifs or by modulating the CRM1-RanGTP interaction, ensuring a more efficient transport process.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Known to inhibit RNA synthesis, it might stress cells and potentially upregulate CRM1 as a response. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
By inhibiting DNA topoisomerase I, it induces DNA damage, possibly leading to altered nuclear transport and CRM1 expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
A ribonucleotide reductase inhibitor that can lead to cell cycle arrest, potentially influencing CRM1 expression. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Induces DNA damage, which might alter nuclear transport dynamics and CRM1 expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Affects DNA synthesis and may influence nuclear transport, potentially impacting CRM1 expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
By inducing DNA damage, it might influence nuclear transport mechanisms and CRM1 expression. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Induces cellular stress and affects various signaling pathways, potentially upregulating CRM1. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that can alter protein homeostasis and potentially influence CRM1 expression. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Influences AMPK signaling and cellular energy status, possibly impacting CRM1 expression. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $36.00 $88.00 $220.00 $436.00 | 8 | |
A cell cycle inhibitor that might affect nuclear transport and CRM1 expression. | ||||||