creatine kinase-M Activators
Creatine kinase-M activators represent a class of molecules demonstrated to upregulate expression of the creatine kinase-M gene. These activators function through diverse intracellular signaling networks to stimulate creatine kinase-M transcription. Many activators activate pathways such as MAPK, Wnt/β-catenin, and cAMP cascades via ligand-mediated receptors or other upstream triggers. Activation of these transduction systems leads to a series of phosphorylation events targeting transcription factors and coregulators imperative for creatine kinase-M gene control. For example, certain activators induce phosphorylation modifications in MEF2 proteins, improving their DNA binding affinity for responsive promoter elements. Others stimulate phosphorylation of histone proteins surrounding the creatine kinase-M locus, making its chromatin more accessible. Several activators foster collaboration between MEF2 factors and other regulatory proteins like AP-1 or ELK1 via phosphorylation signaling. Additionally, some activators block complexes or DNA methylation, alleviating transcriptional suppression of creatine kinase-M.
By modulating multiple cell signaling networks and the phosphorylation state of diverse transcription regulators, creatine kinase-M activators demonstrate varied approaches for overcoming pathways repressing baseline creatine kinase-M expression levels. This ultimately loosens control of the creatine kinase-M gene and augments its mRNA output. Continued research into the specific mechanisms governing individual activator function within modulatory cascades advances the present understanding of natural creatine kinase-M transcriptional dynamics.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1 which deacetylates MEF2, allowing this transcription factor to bind the creatine kinase-M gene promoter and stimulate its expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin reduces HDAC activity, increasing histone acetylation around the creatine kinase-M locus for easier access of transcriptional machinery and increased mRNA synthesis. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
By triggering Nrf2 signaling, DL-Sulforaphane boosts CREB protein levels which help initiate creatine kinase-M transcription upon binding DNA response components. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $54.00 $112.00 $202.00 $700.00 | 6 | |
Silybin blocks DNA methylation of the creatine kinase-M regulatory region via inhibition of DNMTs, facilitating a more permissive state for transcription factor occupancy. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin stimulates the PI3K/Akt pathway, provoking downstream phosphorylation events that positively regulate MEF2 interaction with cognate elements in the creatine kinase-M promoter region. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine triggers calcium spikes, provoking calmodulin binding and activation of CaMKs which phosphorylate members of the MEF2 transcription factor family. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin induces the p38 MAPK module, promoting phosphorylation modifications in MEF2 proteins that improve their efficiency in initiating creatine kinase-M transcription. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein activates PKA through the cAMP pathway, stimulating PKA phosphorylation of histone proteins around the creatine kinase-M locus leading to enhanced gene expression. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol stimulates the Wnt/β-catenin pathway, allowing β-catenin translocation and stimulation of TCF interactions to bind responsive elements and recruit transcriptional cofactors to the creatine kinase-M promoter region. | ||||||
Embelin | 550-24-3 | sc-201555 sc-201555A | 10 mg 50 mg | $87.00 $332.00 | 5 | |
Embelin activates JNK signaling, inducing phosphorylation events in AP-1 complex members that collaborate with MEF2 proteins to bind enhancer components for creatine kinase-M up-regulation. | ||||||