cPKC α Activators
cPKC α Activators are a diverse group of chemical compounds that enhance the functional activity of cPKC α through various signaling pathways and biological processes. Phorbol 12-myristate 13-acetate (PMA) and Bryostatin 1 directly bind to cPKC α, mimicking the physiological activator diacylglycerol, thereby promoting its activation and subsequent phosphorylation events. Similarly, 1,2-Dioctanoyl-sn-glycerol (DiC8) and Indolactam V serve as synthetic activators that bind to the DAG-binding domain, leading to cPKC α activation, which influences gene expression, cell growth, and apoptosis. Prostratin and Ingenol 3,20-dibenzoate activate cPKC α by binding to the C1 domain, modulating cell proliferation, differentiation, and survival while avoiding downregulation. Teleocidin, by acting as a DAG mimetic, and Apigenin, through kinase inhibition, both ensure that cPKC α-mediated pathways are predominant in processes such as transcription factor activation and gene expression related to growth and apoptosis.
The indirect activators of cPKC α, such as Deoxygedunin and Oleoylethanolamide (OEA), enhance its activity through mechanisms involving modulation of intracellular calcium levels and lipid signaling molecules, respectively, thus influencing cPKC α's role in synaptic plasticity, neuroprotection, and metabolic processes. Ceramide indirectly enhances cPKC α by altering membrane lipid composition, which affects the kinase's localization and activity in stress-induced signaling. Lastly, Arachidonic acid serves as a precursor for bioactive lipids that act as secondary messengers, thereby influencing cPKC α activation and modulating crucial cellular functions such as inflammation and smooth muscle contraction.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA functions as a diacylglycerol (DAG) analog, directly binding to and activating cPKC α by mimicking DAG, the physiological activator of cPKC α, thus promoting its translocation to the plasma membrane and subsequent phosphorylation events in the signaling cascade. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 acts as a modulator of cPKC α by binding to the C1 domain, enhancing the affinity of cPKC α for calcium and diacylglycerol, thus increasing its activation and the subsequent signaling through downstream targets involved in cellular processes such as proliferation and differentiation. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $47.00 $254.00 | 2 | |
DiC8 is a synthetic analog of diacylglycerol that can activate cPKC α by engaging with its DAG-binding domain, leading to its activation and the promotion of downstream signaling pathways that cPKC α is involved in, such as the regulation of gene expression, cell growth, and apoptosis. | ||||||
(−)-Indolactam V | 90365-57-4 | sc-202182 sc-202182A | 300 µg 1 mg | $175.00 $350.00 | 1 | |
Indolactam V selectively activates cPKC α by binding to its regulatory domain, which mimics the effects of diacylglycerol, thereby inducing its translocation and activation. This activation initiates a cascade of phosphorylation events, influencing processes such as cell cycle progression and cytoskeletal organization. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $141.00 $541.00 | 24 | |
Prostratin acts similarly to PMA by binding to the C1 domain of cPKC α, which leads to the activation of the kinase and modulation of signaling pathways involved in cell proliferation, differentiation, and survival, without causing the downregulation of cPKC α that can be observed with prolonged PMA treatment. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is a flavonoid that can enhance cPKC α activity indirectly by inhibiting other kinases and cellular signaling components that would otherwise compete with or negatively regulate cPKC α signaling, thereby allowing cPKC α-mediated pathways to become more predominant in cellular functions like cell cycle control and apoptosis. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $90.00 $194.00 | 1 | |
OEA enhances cPKC α activity by serving as a lipid signaling molecule that can bind to peroxisome proliferator-activated receptors (PPARs) and potentially influence lipid signaling pathways to upregulate cPKC α activity, particularly in metabolic processes and inflammation. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Ceramide can indirectly enhance cPKC α activity by modulating cellular stress and apoptosis pathways. The alteration of membrane lipid composition by ceramide can influence the localization and activity of cPKC α, thereby promoting its role in stress-induced signaling and apoptotic responses. | ||||||