CoREST Activators
The class of CoREST activators encompasses a diverse range of chemicals targeting various cellular pathways and processes that may indirectly modulate CoREST activity. These activators can be categorized into several classes based on their primary mechanisms of action, including activation of nuclear receptors, modulation of energy and metabolic pathways, and influence on epigenetic modifications. GW501516, AICAR, and Metformin are activators that influence CoREST indirectly through their impact on cellular energy status and metabolic pathways. Activation of AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-delta (PPAR-delta) can subsequently modulate CoREST as part of the cellular response to changes in energy availability. SRT1720 and Resveratrol activate Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase. Their influence on SIRT1 can affect histone acetylation patterns, modulating CoREST activity as part of the broader epigenetic regulatory network responsive to changes in acetylation status.
Betaine and Nicotinamide impact CoREST indirectly by influencing one-carbon metabolism and nicotinamide adenine dinucleotide (NAD+) availability, respectively. Changes in methyl donor availability and NAD+-dependent enzymes can affect CoREST function as part of the broader epigenetic regulatory network. 5-Azacytidine and Sodium Butyrate are activators that influence CoREST indirectly through their roles as DNA methyltransferase (DNMT) inhibitors and histone deacetylase (HDAC) inhibitors, respectively. Their impact on DNA methylation and histone acetylation patterns can modulate CoREST function as part of the epigenetic regulatory network. Curcumin, Sulforaphane, and Dimethyl Fumarate are activators that modulate CoREST through their effects on various signaling pathways. Curcumin's modulation of signaling pathways, Sulforaphane's activation of nuclear factor erythroid 2-related factor 2 (Nrf2), and Dimethyl Fumarate's activation of Nrf2 can influence CoREST activity as part of the broader cellular response to oxidative stress and environmental stimuli.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516, also known as Cardarine, is a selective agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta). Activation of PPAR-delta by GW501516 can influence gene expression patterns related to energy metabolism and mitochondrial function, which may indirectly impact CoREST activity given its involvement in epigenetic regulation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) is an activator of AMP-activated protein kinase (AMPK). Activation of AMPK by AICAR can modulate cellular energy status and metabolic pathways, potentially influencing CoREST function as part of the epigenetic regulatory network responsive to cellular energy levels. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analogue and DNA methyltransferase (DNMT) inhibitor. By inhibiting DNMTs, 5-Azacytidine induces DNA demethylation, impacting epigenetic regulation. CoREST, as an epigenetic regulator, may be indirectly affected by changes in DNA methylation patterns induced by 5-Azacytidine. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $193.00 $357.00 | 13 | |
SRT1720 is an activator of Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase. Activation of SIRT1 by SRT1720 can influence histone acetylation patterns, potentially modulating CoREST activity as part of the broader epigenetic regulatory network. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $30.00 $40.00 $55.00 $160.00 $330.00 $580.00 | 2 | |
Betaine, a naturally occurring compound, is involved in one-carbon metabolism and serves as a methyl donor. Changes in methyl donor availability, including betaine, can impact DNA and histone methylation patterns, potentially influencing CoREST function as an epigenetic regulator responsive to alterations in methylation status. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin is an anti-diabetic drug that activates AMP-activated protein kinase (AMPK). Activation of AMPK by metformin can modulate cellular energy status and metabolic pathways, potentially influencing CoREST function as part of the epigenetic regulatory network responsive to cellular energy levels. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenolic compound found in red grapes and other plants. It activates Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase. Activation of SIRT1 by resveratrol can influence histone acetylation patterns, potentially modulating CoREST activity as part of the broader epigenetic regulatory network. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide, a form of vitamin B3, is a precursor to nicotinamide adenine dinucleotide (NAD+). NAD+-dependent enzymes, including Sirtuins, can influence epigenetic regulation. Nicotinamide's impact on NAD+ availability may indirectly modulate CoREST activity as part of the broader cellular response to changes in cellular energy and metabolic status. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a short-chain fatty acid and a histone deacetylase (HDAC) inhibitor. Its inhibition of HDACs can influence histone acetylation patterns, potentially modulating CoREST activity as part of the epigenetic regulatory network. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a polyphenolic compound found in turmeric. It has been suggested to modulate various signaling pathways, including those involved in epigenetic regulation. Curcumin's potential influence on these pathways may indirectly impact CoREST function as part of the broader epigenetic regulatory network. | ||||||