CoREST Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275 is a histone deacetylase (HDAC) inhibitor that selectively targets class I HDACs. By inhibiting HDAC activity, MS-275 modulates the acetylation status of histones, influencing chromatin structure and gene expression. This, in turn, can impact the activity of CoREST, a corepressor complex involved in gene silencing. | ||||||
Pargyline hydrochloride | 306-07-0 | sc-215676 sc-215676A | 500 mg 1 g | $39.00 $82.00 | 2 | |
Pargyline is a monoamine oxidase (MAO) inhibitor that affects the metabolism of neurotransmitters. By inhibiting MAO, pargyline can influence the levels of monoamine neurotransmitters, potentially impacting the activity of CoREST, which is implicated in neuronal development and function. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a DNA methyltransferase (DNMT) inhibitor used in epigenetic therapy. Its inhibition of DNMTs leads to hypomethylation of DNA, affecting gene expression patterns. CoREST, being involved in epigenetic regulation, may be indirectly influenced by the altered DNA methylation status induced by decitabine. | ||||||
Tranylcypromine | 13492-01-8 | sc-200572 sc-200572A | 1 g 5 g | $175.00 $599.00 | 5 | |
Tranylcypromine is a nonselective monoamine oxidase inhibitor that can impact neurotransmitter levels. Its potential modulation of monoamines may have downstream effects on CoREST activity, given the complex's involvement in epigenetic regulation in the nervous system. | ||||||
RGFP 109 | 1215493-56-3 | sc-477157 | 10 mg | $300.00 | ||
RGFP 109 has been proposed as a histone acetyltransferase (HAT) activator. By influencing HAT activity, RGFP 109 may indirectly affect the acetylation status of histones, impacting chromatin dynamics and gene expression. CoREST, as an epigenetic regulator, can be modulated by changes in histone acetylation, potentially altering its function. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a selective inhibitor of the histone acetyltransferase p300. Its impact on p300 activity influences histone acetylation patterns, which can affect chromatin structure and gene expression. CoREST, being involved in epigenetic regulation, may be indirectly modulated by the changes in histone acetylation induced by C646. | ||||||
MC 1568 | 852475-26-4 | sc-362767 sc-362767A | 10 mg 50 mg | $179.00 $566.00 | 4 | |
MC1568 is an inhibitor of the histone acetyltransferase CBP. Its impact on CBP activity influences histone acetylation patterns, which can affect chromatin structure and gene expression. CoREST, being involved in epigenetic regulation, may be indirectly modulated by the changes in histone acetylation induced by MC1568. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
EPZ-6438 is a selective inhibitor of the histone methyltransferase EZH2. By inhibiting EZH2, EPZ-6438 can influence histone methylation patterns, potentially affecting the function of the CoREST complex, which is involved in histone demethylation. | ||||||
Tubastatin A | 1252003-15-8 | sc-507298 | 10 mg | $114.00 | ||
Tubastatin A is a selective inhibitor of HDAC6. Its impact on HDAC6 activity influences the acetylation status of non-histone proteins, leading to altered cellular processes. CoREST, involved in epigenetic regulation, may be indirectly influenced by changes in non-histone protein acetylation induced by Tubastatin A. | ||||||