MC 1568 CAS: 852475-26-4
MF: C17H15FN2O3
MW: 314.31
A class II (IIa) HDAC inhibitor selective for HDAC4 and HDAC6.

MC 1568 (CAS 852475-26-4)

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备用名: 3-[5-(3-(3-Fluorophenyl)-3-oxoprope n-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-prope namide
应用; MC 1568 is a class II (IIa) HDAC inhibitor selective for HDAC4 and HDAC6
CAS号码: 852475-26-4
纯度: ≥95%
分子量: 314.31
分子式: C17H15FN2O3
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

MC1568 is a class II (IIa) HDAC inhibitor selective for HDAC4 and HDAC6 (IC50 = 220 nM). MC1568 also inhibits HDAC5.

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in DMSO (100 mM), water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C.
保存 :
Store at 4° C
熔点 :
220.97° C (Predicted)
密度 :
~1.22 g/cm3 (Predicted)
折射率 :
n20D 1.57 (Predicted)
IC50 :
Histone deacetylase 9: IC50 = 220 nM (human); Histone deacetylase 5: IC50 = 220 nM (human); Histone deacetylase 7: IC50 = 220 nM (human); Histone deacetylase 4: IC50 = 220 nM (human); Histone deacetylase 1A: IC50 = 220 nM (maize)
pK值 :
pKa: 8.91 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
11381449
MDL 号码 :
MFCD16875423
SMILES :
CN1C=C(C=C1/C=C/C(=O)NO)/C=C/C(=O)C2=CC(=CC=C2)F

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引用1 - 44

PMID: # 29482060  Choi, SY. et al. 2018. Biomed. Pharmacother. 101: 145-154.

PMID: # 29302209  Kim, M. et al. 2018. Korean J. Physiol. Pharmacol. 22: 23-33.

PMID: # 30424007  Cho, HM. et al. 2018. Int J Mol Sci. 19:

PMID: # 24413532  Kang, HJ. et al. 2014. Cancer research. 74: 1484-94.

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